Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.
Kazi, Julhash U. LU
and Rönnstrand, Lars
LU
(2013)
In Molecular Oncology
7(3).
p.693-703
- Abstract
- The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family of E3 ubiquitin ligases. SOCS2 is known to regulate signal transduction by cytokine receptors and receptor tyrosine kinases. The receptor tyrosine kinase FLT3 is of importance for proliferation, survival and differentiation of hematopoietic cells and is frequently mutated in acute myeloid leukemia. We observed that SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. SOCS2 increases FLT3 ubiquitination and accelerates receptor degradation in proteasomes. SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5. Furthermore, SOCS2 expression leads to a... (More)
- The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family of E3 ubiquitin ligases. SOCS2 is known to regulate signal transduction by cytokine receptors and receptor tyrosine kinases. The receptor tyrosine kinase FLT3 is of importance for proliferation, survival and differentiation of hematopoietic cells and is frequently mutated in acute myeloid leukemia. We observed that SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. SOCS2 increases FLT3 ubiquitination and accelerates receptor degradation in proteasomes. SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5. Furthermore, SOCS2 expression leads to a decrease in FLT3-ITD-mediated cell proliferation and colony formation. Thus, we suggest that SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3734284
- author
- Kazi, Julhash U.
LU
and Rönnstrand, Lars
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Molecular Oncology
- volume
- 7
- issue
- 3
- pages
- 693 - 703
- publisher
- Elsevier
- external identifiers
-
- wos:000321233400032
- pmid:23548639
- scopus:84878110355
- pmid:23548639
- ISSN
- 1574-7891
- DOI
- 10.1016/j.molonc.2013.02.020
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
- id
- c7015283-9740-4713-b623-658640aa44a9 (old id 3734284)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23548639?dopt=Abstract
- date added to LUP
- 2016-04-01 10:32:25
- date last changed
- 2022-04-27 23:04:18
@article{c7015283-9740-4713-b623-658640aa44a9,
abstract = {{The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family of E3 ubiquitin ligases. SOCS2 is known to regulate signal transduction by cytokine receptors and receptor tyrosine kinases. The receptor tyrosine kinase FLT3 is of importance for proliferation, survival and differentiation of hematopoietic cells and is frequently mutated in acute myeloid leukemia. We observed that SOCS2 associates with activated FLT3 through phosphotyrosine residues 589 and 919, and co-localizes with FLT3 in the cell membrane. SOCS2 increases FLT3 ubiquitination and accelerates receptor degradation in proteasomes. SOCS2 negatively regulates FLT3 signaling by blocking activation of Erk 1/2 and STAT5. Furthermore, SOCS2 expression leads to a decrease in FLT3-ITD-mediated cell proliferation and colony formation. Thus, we suggest that SOCS2 associates with activated FLT3 and negatively regulates the FLT3 signaling pathways.}},
author = {{Kazi, Julhash U. and Rönnstrand, Lars}},
issn = {{1574-7891}},
language = {{eng}},
number = {{3}},
pages = {{693--703}},
publisher = {{Elsevier}},
series = {{Molecular Oncology}},
title = {{Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling.}},
url = {{https://lup.lub.lu.se/search/files/1931105/4053918.pdf}},
doi = {{10.1016/j.molonc.2013.02.020}},
volume = {{7}},
year = {{2013}},
}