Developing dopaminergic cell therapy for Parkinson's disease-give up or move forward?
(2013) In Movement Disorders 28(3). p.268-273- Abstract
- Despite 3 decades of basic and clinical studies, there is still no dopaminergic cell therapy for Parkinson's disease. Several arguments have been put forward why this approach, so far tested with transplantation of human fetal mesencephalic dopamine-rich tissue, will never be of clinical use and should be abandoned: (1) Lack of efficacy in 2 sham surgery-controlled trials; (2) occurrence of troublesome off-medication dyskinesias in a subgroup of grafted patients; (3) disease process destroys grafted neurons; and (4) non-motor symptoms will not be influenced by intrastriatal dopaminergic grafts. Here, the author argues that, based on recent scientific advancements, the development of a dopaminergic cell therapy for Parkinson's disease... (More)
- Despite 3 decades of basic and clinical studies, there is still no dopaminergic cell therapy for Parkinson's disease. Several arguments have been put forward why this approach, so far tested with transplantation of human fetal mesencephalic dopamine-rich tissue, will never be of clinical use and should be abandoned: (1) Lack of efficacy in 2 sham surgery-controlled trials; (2) occurrence of troublesome off-medication dyskinesias in a subgroup of grafted patients; (3) disease process destroys grafted neurons; and (4) non-motor symptoms will not be influenced by intrastriatal dopaminergic grafts. Here, the author argues that, based on recent scientific advancements, the development of a dopaminergic cell therapy for Parkinson's disease should continue. Factors influencing the outcome after transplantation have now been identified, and dopaminergic neurons can be generated in large numbers from stem cells. Mechanisms of graft-induced dyskinesias are much better understood, and patients with well functioning grafts can exhibit long-term motor recovery of therapeutic value even in the presence of non-motor symptoms. © 2013 Movement Disorder Society. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3559883
- author
- Lindvall, Olle LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Movement Disorders
- volume
- 28
- issue
- 3
- pages
- 268 - 273
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000316696700005
- pmid:23401015
- scopus:84875497155
- pmid:23401015
- ISSN
- 0885-3185
- DOI
- 10.1002/mds.25378
- language
- English
- LU publication?
- yes
- id
- 3797129f-ca47-44c7-a2f1-a133a8ff868a (old id 3559883)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23401015?dopt=Abstract
- date added to LUP
- 2016-04-01 11:03:19
- date last changed
- 2022-05-18 08:00:46
@misc{3797129f-ca47-44c7-a2f1-a133a8ff868a,
abstract = {{Despite 3 decades of basic and clinical studies, there is still no dopaminergic cell therapy for Parkinson's disease. Several arguments have been put forward why this approach, so far tested with transplantation of human fetal mesencephalic dopamine-rich tissue, will never be of clinical use and should be abandoned: (1) Lack of efficacy in 2 sham surgery-controlled trials; (2) occurrence of troublesome off-medication dyskinesias in a subgroup of grafted patients; (3) disease process destroys grafted neurons; and (4) non-motor symptoms will not be influenced by intrastriatal dopaminergic grafts. Here, the author argues that, based on recent scientific advancements, the development of a dopaminergic cell therapy for Parkinson's disease should continue. Factors influencing the outcome after transplantation have now been identified, and dopaminergic neurons can be generated in large numbers from stem cells. Mechanisms of graft-induced dyskinesias are much better understood, and patients with well functioning grafts can exhibit long-term motor recovery of therapeutic value even in the presence of non-motor symptoms. © 2013 Movement Disorder Society.}},
author = {{Lindvall, Olle}},
issn = {{0885-3185}},
language = {{eng}},
number = {{3}},
pages = {{268--273}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Movement Disorders}},
title = {{Developing dopaminergic cell therapy for Parkinson's disease-give up or move forward?}},
url = {{http://dx.doi.org/10.1002/mds.25378}},
doi = {{10.1002/mds.25378}},
volume = {{28}},
year = {{2013}},
}