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Video capsule endoscopy in pediatric patients with Crohn’s disease : a single-center experience of 180 procedures

Nemeth, Artur LU ; Agardh, Daniel LU ; Wurm Johansson, Gabriele LU ; Thorlacius, Henrik LU and Toth, Ervin LU (2018) In Therapeutic Advances in Gastroenterology 11.
Abstract

Background: Video capsule endoscopy (VCE) is a noninvasive method enabling excellent visualization of the small bowel (SB) mucosa. The aim of this study was to examine the impact and safety of VCE performed in children and adolescents with suspected or established Crohn’s disease (CD). Methods: A total of 180 VCE examinations in 169 consecutive patients conducted in 2003–14 in a single center were retrospectively analyzed. The median age was 13 years (range 3–17 years) and indications for VCE were suspected (125 cases, 69%) and established (55 cases, 31%) CD. VCE was performed with a PillCam SB (Given Imaging, Yokneam, Israel) VCE system with 8–12 h of registration without bowel preparation. Results: A total of 154 of 180 (86%) patients... (More)

Background: Video capsule endoscopy (VCE) is a noninvasive method enabling excellent visualization of the small bowel (SB) mucosa. The aim of this study was to examine the impact and safety of VCE performed in children and adolescents with suspected or established Crohn’s disease (CD). Methods: A total of 180 VCE examinations in 169 consecutive patients conducted in 2003–14 in a single center were retrospectively analyzed. The median age was 13 years (range 3–17 years) and indications for VCE were suspected (125 cases, 69%) and established (55 cases, 31%) CD. VCE was performed with a PillCam SB (Given Imaging, Yokneam, Israel) VCE system with 8–12 h of registration without bowel preparation. Results: A total of 154 of 180 (86%) patients swallowed the capsule and 26 (14%) had the capsule endoscopically placed in the duodenum. Patency capsule examination was performed in 71 cases prior to VCE to exclude SB obstruction. VCE detected findings consistent with SB CD in 71 (40%) examinations and 17 (9%) procedures showed minor changes not diagnostic for CD. A total of 92 (51%) examinations displayed normal SB mucosa. The capsule did not reach the colon within the recording time in 30 (17%) procedures and were defined as incomplete examinations. A change in diagnosis or therapy was recommended in 56 (31%) patients based on VCE results. Capsule retention occurred in one patient. Conclusions: VCE is a safe method in children with suspected or established CD. VCE often leads to a definitive diagnosis and has a significant impact on the clinical management of pediatric patients with CD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
capsule endoscopy, children, Crohn’s disease, small bowel
in
Therapeutic Advances in Gastroenterology
volume
11
publisher
SAGE Publications Inc.
external identifiers
  • scopus:85054839445
ISSN
1756-283X
DOI
10.1177/1756284818758929
language
English
LU publication?
yes
id
37a2d4de-ae4c-4e21-8c99-0e656e3f2834
date added to LUP
2018-11-06 12:46:32
date last changed
2019-01-14 18:06:45
@article{37a2d4de-ae4c-4e21-8c99-0e656e3f2834,
  abstract     = {<p>Background: Video capsule endoscopy (VCE) is a noninvasive method enabling excellent visualization of the small bowel (SB) mucosa. The aim of this study was to examine the impact and safety of VCE performed in children and adolescents with suspected or established Crohn’s disease (CD). Methods: A total of 180 VCE examinations in 169 consecutive patients conducted in 2003–14 in a single center were retrospectively analyzed. The median age was 13 years (range 3–17 years) and indications for VCE were suspected (125 cases, 69%) and established (55 cases, 31%) CD. VCE was performed with a PillCam SB (Given Imaging, Yokneam, Israel) VCE system with 8–12 h of registration without bowel preparation. Results: A total of 154 of 180 (86%) patients swallowed the capsule and 26 (14%) had the capsule endoscopically placed in the duodenum. Patency capsule examination was performed in 71 cases prior to VCE to exclude SB obstruction. VCE detected findings consistent with SB CD in 71 (40%) examinations and 17 (9%) procedures showed minor changes not diagnostic for CD. A total of 92 (51%) examinations displayed normal SB mucosa. The capsule did not reach the colon within the recording time in 30 (17%) procedures and were defined as incomplete examinations. A change in diagnosis or therapy was recommended in 56 (31%) patients based on VCE results. Capsule retention occurred in one patient. Conclusions: VCE is a safe method in children with suspected or established CD. VCE often leads to a definitive diagnosis and has a significant impact on the clinical management of pediatric patients with CD.</p>},
  articleno    = {175628481875892},
  author       = {Nemeth, Artur and Agardh, Daniel and Wurm Johansson, Gabriele and Thorlacius, Henrik and Toth, Ervin},
  issn         = {1756-283X},
  keyword      = {capsule endoscopy,children,Crohn’s disease,small bowel},
  language     = {eng},
  month        = {03},
  publisher    = {SAGE Publications Inc.},
  series       = {Therapeutic Advances in Gastroenterology},
  title        = {Video capsule endoscopy in pediatric patients with Crohn’s disease : a single-center experience of 180 procedures},
  url          = {http://dx.doi.org/10.1177/1756284818758929},
  volume       = {11},
  year         = {2018},
}