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Fiber intake modulates the association of alcohol intake with breast cancer

Romieu, Isabelle; Ferrari, Pietro; Chajès, Veronique; de Batlle, Jordi; Biessy, Carine; Scoccianti, Chiara; Dossus, Laure; Christine Boutron, Marie; Bastide, Nadia and Overvad, Kim, et al. (2017) In International Journal of Cancer 140(2). p.316-321
Abstract

Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and... (More)

Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (<18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (>24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (<18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.

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published
subject
keywords
alcohol, breast cancer, epidemiology, nutrition
in
International Journal of Cancer
volume
140
issue
2
pages
316 - 321
publisher
John Wiley & Sons
external identifiers
  • scopus:84995932379
  • wos:000390703600007
ISSN
0020-7136
DOI
10.1002/ijc.30415
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English
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yes
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38732062-a382-403f-8b68-712db346d7bf
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2016-12-05 09:14:25
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2018-01-07 11:38:39
@article{38732062-a382-403f-8b68-712db346d7bf,
  abstract     = {<p>Alcohol intake has been related to an increased risk of breast cancer (BC) while dietary fiber intake has been inversely associated to BC risk. A beneficial effect of fibers on ethanol carcinogenesis through their impact on estrogen levels is still controversial. We investigated the role of dietary fiber as a modifying factor of the association of alcohol and BC using data from the European Prospective Investigation into Cancer and Nutrition (EPIC). This study included 334,850 women aged 35–70 years at baseline enrolled in the ten countries of the EPIC study and followed up for 11.0 years on average. Information on fiber and alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. Hazard ratios (HR) of developing invasive BC according to different levels of alcohol and fiber intake were computed. During 3,670,439 person-years, 11,576 incident BC cases were diagnosed. For subjects with low intake of fiber (&lt;18.5 g/day), the risk of BC per 10 g/day of alcohol intake was 1.06 (1.03–1.08) while among subjects with high intake of fiber (&gt;24.2 g/day) the risk of BC was 1.02 (0.99–1.05) (test for interaction p = 0.011). This modulating effect was stronger for fiber from vegetables. Our results suggest that fiber intake may modulate the positive association of alcohol intake and BC. Alcohol is well known to increase the risk for BC, while a fiber-rich diet has the opposite effect. Here the authors find a significant interaction between both lifestyle factors indicating that high fiber intake can ease the adverse effects associated with alcohol consumption. Consequently, women with high alcohol intake and low fiber intake (&lt;18.5 g/day) had the highest risk for BC. Specific benefits were associated with fibers from vegetable, warranting further investigations into specific fiber sources and their mechanistic interactions with alcohol-induced BC risk.</p>},
  author       = {Romieu, Isabelle and Ferrari, Pietro and Chajès, Veronique and de Batlle, Jordi and Biessy, Carine and Scoccianti, Chiara and Dossus, Laure and Christine Boutron, Marie and Bastide, Nadia and Overvad, Kim and Olsen, Anja and Tjønneland, Anne and Kaaks, Rudolf and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Palli, Domenico and Sieri, Sabina and Tumino, Rosario and Vineis, Paolo and Panico, Salvatore and Bueno-de-Mesquita, H. Bas and Gils, Carla H. and Peeters, Petra H. and Lund, Eiliv and Skeie, Guri and Weiderpass, Elisabete and Ramón Quirós, J. and Chirlaque, María Dolores and Ardanaz, Eva and Sánchez, María José and Duell, Eric J. and Amiano Etxezarreta, Pilar and Borgquist, Signe and Hallmans, Göran and Johansson, Ingegerd and Maria Nilsson, Lena and Khaw, Kay Tee and Wareham, Nick and Key, Timothy J. and Travis, Ruth C. and Murphy, Neil and Wark, Petra A. and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {alcohol,breast cancer,epidemiology,nutrition},
  language     = {eng},
  month        = {01},
  number       = {2},
  pages        = {316--321},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Fiber intake modulates the association of alcohol intake with breast cancer},
  url          = {http://dx.doi.org/10.1002/ijc.30415},
  volume       = {140},
  year         = {2017},
}