Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation
(2021) In Atherosclerosis 335. p.47-52- Abstract
Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common... (More)
Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61–0.97] mm vs. 0.58 [0.53–0.76] mm, p < 0.003) and in women compared to controls (0.83 [0.70–0.92] vs. 0.60 [0.55–0.69], p < 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015). Conclusions: This is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.
(Less)
- author
- Hlebowicz, Joanna LU ; Holm, Johan LU ; Lindstedt, Sandra LU ; Goncalves, Isabel LU and Nilsson, Jan LU
- organization
-
- Cardiology
- Clinical and experimental lung transplantation (research group)
- DCD transplantation of lungs (research group)
- NPWT technology (research group)
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- EXODIAB: Excellence of Diabetes Research in Sweden
- Cardiovascular Research - Translational Studies (research group)
- EpiHealth: Epidemiology for Health
- Cardiovascular Research - Immunity and Atherosclerosis (research group)
- publishing date
- 2021-10-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aortic coarctation, Atherosclerosis, Biomarkers, Carotid atherosclerosis
- in
- Atherosclerosis
- volume
- 335
- pages
- 6 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:34564048
- scopus:85115746028
- ISSN
- 0021-9150
- DOI
- 10.1016/j.atherosclerosis.2021.09.016
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Author(s)
- id
- 388832cf-6ee9-46c7-91d1-9cb0af9f1258
- date added to LUP
- 2021-11-19 14:46:05
- date last changed
- 2024-09-08 04:48:30
@article{388832cf-6ee9-46c7-91d1-9cb0af9f1258, abstract = {{<p>Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61–0.97] mm vs. 0.58 [0.53–0.76] mm, p < 0.003) and in women compared to controls (0.83 [0.70–0.92] vs. 0.60 [0.55–0.69], p < 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015). Conclusions: This is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.</p>}}, author = {{Hlebowicz, Joanna and Holm, Johan and Lindstedt, Sandra and Goncalves, Isabel and Nilsson, Jan}}, issn = {{0021-9150}}, keywords = {{Aortic coarctation; Atherosclerosis; Biomarkers; Carotid atherosclerosis}}, language = {{eng}}, month = {{10}}, pages = {{47--52}}, publisher = {{Elsevier}}, series = {{Atherosclerosis}}, title = {{Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation}}, url = {{http://dx.doi.org/10.1016/j.atherosclerosis.2021.09.016}}, doi = {{10.1016/j.atherosclerosis.2021.09.016}}, volume = {{335}}, year = {{2021}}, }