Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation

Hlebowicz, Joanna LU ; Holm, Johan LU ; Lindstedt, Sandra LU ; Goncalves, Isabel LU orcid and Nilsson, Jan LU (2021) In Atherosclerosis 335. p.47-52
Abstract

Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common... (More)

Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61–0.97] mm vs. 0.58 [0.53–0.76] mm, p < 0.003) and in women compared to controls (0.83 [0.70–0.92] vs. 0.60 [0.55–0.69], p < 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015). Conclusions: This is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aortic coarctation, Atherosclerosis, Biomarkers, Carotid atherosclerosis
in
Atherosclerosis
volume
335
pages
6 pages
publisher
Elsevier
external identifiers
  • scopus:85115746028
  • pmid:34564048
ISSN
0021-9150
DOI
10.1016/j.atherosclerosis.2021.09.016
language
English
LU publication?
yes
additional info
Publisher Copyright: © 2021 The Author(s)
id
388832cf-6ee9-46c7-91d1-9cb0af9f1258
date added to LUP
2021-11-19 14:46:05
date last changed
2024-06-15 20:45:05
@article{388832cf-6ee9-46c7-91d1-9cb0af9f1258,
  abstract     = {{<p>Background and aims: After aortic coarctation (CoA) repair, patients still suffer from cardiovascular complications. The aim of this study was to measure cardiovascular markers, intima-media thickness (IMT) and plaques in controls and patients with CoA. Methods: Sixty-four patients with CoA (66% male, mean age 48 ± 15 years) and controls (54% men, mean age 47 ± 16 years) underwent ultrasound of their arteries. A multiplex platform to analyze circulating blood levels biomarkers reflecting inflammation, tissue remodeling and repair was used. Results: In men following CoA repair, a significantly increased carotid bulb IMT was observed in comparison to the control group (1.05 [0.72–1.24] vs. 0.67 [0.59–0.95] mm; p = 0.003). Median common carotid artery (CCA) IMT was increased in men compared to controls (0.82 [0.61–0.97] mm vs. 0.58 [0.53–0.76] mm, p &lt; 0.003) and in women compared to controls (0.83 [0.70–0.92] vs. 0.60 [0.55–0.69], p &lt; 0.004). CoA demonstrated an independent association with IMT in both men and women. Men with CoA were also more likely to have a plaque in their carotid arteries (p = 0.010). In women with CoA, we observed significantly lower levels of stem cell factor (SCF, p = 0.004) while in men with CoA we observed significantly lower levels of matrix metalloproteinase-3 (MMP-3, p = 0.048), tumor necrosis factor receptor 1 (TNF-R1, p = 0.032), tumor necrosis factor receptor superfamily member 10B (TRAIL-R2, p = 0.019) and monocyte chemotactic protein 1 (MCP-1, p = 0.015). Conclusions: This is the first study to show that despite successful CoA repair, patients have more carotid atherosclerosis than can be explained by changes in tissue remodeling and repair.</p>}},
  author       = {{Hlebowicz, Joanna and Holm, Johan and Lindstedt, Sandra and Goncalves, Isabel and Nilsson, Jan}},
  issn         = {{0021-9150}},
  keywords     = {{Aortic coarctation; Atherosclerosis; Biomarkers; Carotid atherosclerosis}},
  language     = {{eng}},
  month        = {{10}},
  pages        = {{47--52}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Carotid atherosclerosis, changes in tissue remodeling and repair in patients with aortic coarctation}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2021.09.016}},
  doi          = {{10.1016/j.atherosclerosis.2021.09.016}},
  volume       = {{335}},
  year         = {{2021}},
}