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GSM 900 MHz exposure of Transgenic GFAP-Mice: A study of histopathology, Tumour induction and BBB leakage

Salford, Leif LU ; Brun, Arne LU and Persson, Bertil R LU (2012) In Acta Scientiarum Lundensia 2012-003. p.1-17
Abstract
Abstract. In previous work we have studied the effects of electromagnetic fields upon

the promotion of growth of tumours from two different rat glioma cell lines, RG2 and N32,

inoculated in the brains of Fischer 344 rats. No promotions of tumour growth due to the

EMF could be demonstrated in large series of animals as compared to their matched

controls. In the present study we have utilized a newly generated "knock-out" mouse

model. By the use of gene targeting, Pekny et al. have created mice deficient for glial

fibrillary acidic protein (GFAP), which is an astrocyte-specific protein that forms

intermediate filaments in the cytoskeleton of astrocytes. The GFAP-deficient mice... (More)
Abstract. In previous work we have studied the effects of electromagnetic fields upon

the promotion of growth of tumours from two different rat glioma cell lines, RG2 and N32,

inoculated in the brains of Fischer 344 rats. No promotions of tumour growth due to the

EMF could be demonstrated in large series of animals as compared to their matched

controls. In the present study we have utilized a newly generated "knock-out" mouse

model. By the use of gene targeting, Pekny et al. have created mice deficient for glial

fibrillary acidic protein (GFAP), which is an astrocyte-specific protein that forms

intermediate filaments in the cytoskeleton of astrocytes. The GFAP-deficient mice utilized

by us develop spontaneous tumours, both lymphoblastic (non-Hodgkin) lymphomas and

Anaplastic rapidly growing tumours diagnosed as malignant Swannomas. The test system

consists of four TEM-cells. A GSM telephone is hooked up to a terminal program on a

computer that controls the power and repetition of pulses. The rats were exposed for about

8 hours during 43 days for a total time of 1143 hours.

In male GFAP-mice we found tumours in all 6 controls and in 4 out of 6 exposed. We

found, however, no tumours in FM controls and in seven exposed FM mice we fund only 1

tumour. Microwave exposure revealed no significant effect on tumour evolution in the

GFAP-mice.

In the CBA-mice microwave exposure gave no significant results of BBB-leakage. But

for the CBA-mice BBB-leakage after microwave exposure of CBA-mice was found

probable at a 99% significance-level. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
900 MHz. exposure, GFAP, Transgenic Mice, tumour induction, BBB leakage, GSM
in
Acta Scientiarum Lundensia
volume
2012-003
pages
1 - 17
publisher
Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden
ISSN
1651-5013
language
English
LU publication?
yes
id
a5a631de-0f6f-49d7-9e9a-692359f7cd39 (old id 3910692)
date added to LUP
2015-05-27 12:22:54
date last changed
2016-04-15 23:36:20
@article{a5a631de-0f6f-49d7-9e9a-692359f7cd39,
  abstract     = {Abstract. In previous work we have studied the effects of electromagnetic fields upon<br/><br>
the promotion of growth of tumours from two different rat glioma cell lines, RG2 and N32,<br/><br>
inoculated in the brains of Fischer 344 rats. No promotions of tumour growth due to the<br/><br>
EMF could be demonstrated in large series of animals as compared to their matched<br/><br>
controls. In the present study we have utilized a newly generated "knock-out" mouse<br/><br>
model. By the use of gene targeting, Pekny et al. have created mice deficient for glial<br/><br>
fibrillary acidic protein (GFAP), which is an astrocyte-specific protein that forms<br/><br>
intermediate filaments in the cytoskeleton of astrocytes. The GFAP-deficient mice utilized<br/><br>
by us develop spontaneous tumours, both lymphoblastic (non-Hodgkin) lymphomas and<br/><br>
Anaplastic rapidly growing tumours diagnosed as malignant Swannomas. The test system<br/><br>
consists of four TEM-cells. A GSM telephone is hooked up to a terminal program on a<br/><br>
computer that controls the power and repetition of pulses. The rats were exposed for about<br/><br>
8 hours during 43 days for a total time of 1143 hours.<br/><br>
In male GFAP-mice we found tumours in all 6 controls and in 4 out of 6 exposed. We<br/><br>
found, however, no tumours in FM controls and in seven exposed FM mice we fund only 1<br/><br>
tumour. Microwave exposure revealed no significant effect on tumour evolution in the<br/><br>
GFAP-mice.<br/><br>
In the CBA-mice microwave exposure gave no significant results of BBB-leakage. But<br/><br>
for the CBA-mice BBB-leakage after microwave exposure of CBA-mice was found<br/><br>
probable at a 99% significance-level.},
  author       = {Salford, Leif and Brun, Arne and Persson, Bertil R},
  issn         = {1651-5013},
  keyword      = {900 MHz. exposure,GFAP,Transgenic Mice,tumour induction,BBB leakage,GSM},
  language     = {eng},
  pages        = {1--17},
  publisher    = {Bertil RR Persson, Medical Radiation Physics, 22185 Lund, Sweden},
  series       = {Acta Scientiarum Lundensia},
  title        = {GSM 900 MHz exposure of Transgenic GFAP-Mice: A study of histopathology, Tumour induction and BBB leakage},
  volume       = {2012-003},
  year         = {2012},
}