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Stimulating effect of pancreatic-like enzymes on the development of the gastrointestinal tract in piglets

Slupecka, M.; Wolinski, J.; Prykhodko, O.; Ochniewicz, P.; Gruijc, D.; Fedkiv, O.; Weström, Björn LU and Pierzynowski, Stefan LU (2012) In Journal of Animal Science 90. p.311-314
Abstract
Use of nutritional components from the milk and eventually from the solid feed relates to the growth and development of gastrointestinal tract (GIT). We studied the effect of pancreatic-like enzymes [porcine pancreatic enzymes (Creon) or microbial-derived amylase, protease, and lipase] on GIT morphology and lipid absorption in suckling piglets. Both enzyme preparations, in low or high dose, were fed via a stomach tube twice a day for 7 d starting at 8 d of age and controls received vehicle, n = 6. The day after treatments ended, lipid absorption was tested after which pigs were euthanized and GIT was examined. Enzyme cocktails, irrespective of their origin, increased (P < 0.001) triglyceride level in blood. Enzyme preparation affected... (More)
Use of nutritional components from the milk and eventually from the solid feed relates to the growth and development of gastrointestinal tract (GIT). We studied the effect of pancreatic-like enzymes [porcine pancreatic enzymes (Creon) or microbial-derived amylase, protease, and lipase] on GIT morphology and lipid absorption in suckling piglets. Both enzyme preparations, in low or high dose, were fed via a stomach tube twice a day for 7 d starting at 8 d of age and controls received vehicle, n = 6. The day after treatments ended, lipid absorption was tested after which pigs were euthanized and GIT was examined. Enzyme cocktails, irrespective of their origin, increased (P < 0.001) triglyceride level in blood. Enzyme preparation affected (P < 0.001) small intestinal mucosal thickness, villi length, and crypt depth and (P < 0.01) mitotic division of enterocytes. In addition, the external administration of pancreatic enzymes stimulated pancreatic growth as observed by increased (P < 0.05) mitotic division of pancreatic cells. The study revealed that pancreatic or pancreatic-like enzymes of microbial origin administrated in the early postperinatal period enhance GIT development and may be used to better prepare the GIT of piglets for milk use and weaning. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
enzyme, gut, maturation, pancreas, suckling pig
in
Journal of Animal Science
volume
90
pages
311 - 314
publisher
American Society of Animal Science
external identifiers
  • wos:000319673100100
  • scopus:84882569025
ISSN
1525-3163
DOI
10.2527/jas53921
language
English
LU publication?
yes
id
c7e5c93d-4007-47f4-873a-5b7bfa0bc237 (old id 3931351)
date added to LUP
2013-07-15 14:54:29
date last changed
2017-01-01 03:38:33
@article{c7e5c93d-4007-47f4-873a-5b7bfa0bc237,
  abstract     = {Use of nutritional components from the milk and eventually from the solid feed relates to the growth and development of gastrointestinal tract (GIT). We studied the effect of pancreatic-like enzymes [porcine pancreatic enzymes (Creon) or microbial-derived amylase, protease, and lipase] on GIT morphology and lipid absorption in suckling piglets. Both enzyme preparations, in low or high dose, were fed via a stomach tube twice a day for 7 d starting at 8 d of age and controls received vehicle, n = 6. The day after treatments ended, lipid absorption was tested after which pigs were euthanized and GIT was examined. Enzyme cocktails, irrespective of their origin, increased (P &lt; 0.001) triglyceride level in blood. Enzyme preparation affected (P &lt; 0.001) small intestinal mucosal thickness, villi length, and crypt depth and (P &lt; 0.01) mitotic division of enterocytes. In addition, the external administration of pancreatic enzymes stimulated pancreatic growth as observed by increased (P &lt; 0.05) mitotic division of pancreatic cells. The study revealed that pancreatic or pancreatic-like enzymes of microbial origin administrated in the early postperinatal period enhance GIT development and may be used to better prepare the GIT of piglets for milk use and weaning.},
  author       = {Slupecka, M. and Wolinski, J. and Prykhodko, O. and Ochniewicz, P. and Gruijc, D. and Fedkiv, O. and Weström, Björn and Pierzynowski, Stefan},
  issn         = {1525-3163},
  keyword      = {enzyme,gut,maturation,pancreas,suckling pig},
  language     = {eng},
  pages        = {311--314},
  publisher    = {American Society of Animal Science},
  series       = {Journal of Animal Science},
  title        = {Stimulating effect of pancreatic-like enzymes on the development of the gastrointestinal tract in piglets},
  url          = {http://dx.doi.org/10.2527/jas53921},
  volume       = {90},
  year         = {2012},
}