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Fully quantitative cardiovascular magnetic resonance myocardial perfusion ready for clinical use : A comparison between cardiovascular magnetic resonance imaging and positron emission tomography

Engblom, Henrik LU ; Xue, Hui; Akil, Shahnaz LU ; Carlsson, Marcus LU ; Hindorf, Cecilia LU ; Oddstig, Jenny LU ; Hedeer, Fredrik LU ; Hansen, Michael S.; Aletras, Anthony H. LU and Kellman, Peter, et al. (2017) In Journal of Cardiovascular Magnetic Resonance 19(1).
Abstract

Background: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow. The aim of this study was to validate the use of the automated CMR perfusion mapping technique for quantification of MP using 13N-NH3 cardiac positron emission tomography (PET) as the reference method. Methods: Twenty-one patients with stable CAD... (More)

Background: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow. The aim of this study was to validate the use of the automated CMR perfusion mapping technique for quantification of MP using 13N-NH3 cardiac positron emission tomography (PET) as the reference method. Methods: Twenty-one patients with stable CAD were included in the study. All patients underwent adenosine stress and rest perfusion imaging with 13N-NH3 PET and a dual sequence, single contrast bolus CMR on the same day. Global and regional MP were quantified both at stress and rest using PET and CMR. Results: There was good agreement between global MP quantified by PET and CMR both at stress (-0.1 ± 0.5 ml/min/g) and at rest (0 ± 0.2 ml/min/g) with a strong correlation (r = 0.92, p < 0.001; y = 0.94× + 0.14). Furthermore, there was strong correlation between CMR and PET with regards to regional MP (r = 0.83, p < 0.001; y = 0.87× + 0.26) with a good agreement (-0.1 ± 0.6 ml/min/g). There was also a significant correlation between CMR and PET with regard to global and regional MPR (r = 0.69, p = 0.001 and r = 0.57, p < 0.001, respectively). Conclusions: There is good agreement between MP quantified by 13N-NH3 PET and dual sequence, single contrast bolus CMR in patients with stable CAD. Thus, CMR is viable in clinical practice for quantification of MP.

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published
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keywords
Cardiac magnetic resonance, Myocardial perfusion, Myocardial perfusion reserve, Positron emission tomography
in
Journal of Cardiovascular Magnetic Resonance
volume
19
issue
1
publisher
BioMed Central
external identifiers
  • scopus:85031755035
  • wos:000413253200001
ISSN
1097-6647
DOI
10.1186/s12968-017-0388-9
language
English
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yes
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39413ac5-3390-414b-a1df-e9101797e210
date added to LUP
2017-11-08 09:12:00
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2018-05-20 04:38:41
@article{39413ac5-3390-414b-a1df-e9101797e210,
  abstract     = {<p>Background: Recent studies have shown that quantification of myocardial perfusion (MP) at stress and myocardial perfusion reserve (MPR) offer additional diagnostic and prognostic information compared to qualitative and semi-quantitative assessment of myocardial perfusion distribution in patients with coronary artery disease (CAD). Technical advancements have enabled fully automatic quantification of MP using cardiovascular magnetic resonance (CMR) to be performed in-line in a clinical workflow. The aim of this study was to validate the use of the automated CMR perfusion mapping technique for quantification of MP using 13N-NH3 cardiac positron emission tomography (PET) as the reference method. Methods: Twenty-one patients with stable CAD were included in the study. All patients underwent adenosine stress and rest perfusion imaging with 13N-NH3 PET and a dual sequence, single contrast bolus CMR on the same day. Global and regional MP were quantified both at stress and rest using PET and CMR. Results: There was good agreement between global MP quantified by PET and CMR both at stress (-0.1 ± 0.5 ml/min/g) and at rest (0 ± 0.2 ml/min/g) with a strong correlation (r = 0.92, p &lt; 0.001; y = 0.94× + 0.14). Furthermore, there was strong correlation between CMR and PET with regards to regional MP (r = 0.83, p &lt; 0.001; y = 0.87× + 0.26) with a good agreement (-0.1 ± 0.6 ml/min/g). There was also a significant correlation between CMR and PET with regard to global and regional MPR (r = 0.69, p = 0.001 and r = 0.57, p &lt; 0.001, respectively). Conclusions: There is good agreement between MP quantified by 13N-NH3 PET and dual sequence, single contrast bolus CMR in patients with stable CAD. Thus, CMR is viable in clinical practice for quantification of MP.</p>},
  articleno    = {78},
  author       = {Engblom, Henrik and Xue, Hui and Akil, Shahnaz and Carlsson, Marcus and Hindorf, Cecilia and Oddstig, Jenny and Hedeer, Fredrik and Hansen, Michael S. and Aletras, Anthony H. and Kellman, Peter and Arheden, Håkan},
  issn         = {1097-6647},
  keyword      = {Cardiac magnetic resonance,Myocardial perfusion,Myocardial perfusion reserve,Positron emission tomography},
  language     = {eng},
  month        = {10},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Cardiovascular Magnetic Resonance},
  title        = {Fully quantitative cardiovascular magnetic resonance myocardial perfusion ready for clinical use : A comparison between cardiovascular magnetic resonance imaging and positron emission tomography},
  url          = {http://dx.doi.org/10.1186/s12968-017-0388-9},
  volume       = {19},
  year         = {2017},
}