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MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia

Panagopoulos, Ioannis LU ; Lilljebjörn, Henrik LU orcid ; Strömbeck, Bodil LU ; Hjorth, Lars LU ; Olofsson, Tor LU and Johansson, Bertil LU (2006) In Haematologica 91(9). p.1287-1288
Abstract
AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
GAS7, MLL, ALL, translocation, fusion
in
Haematologica
volume
91
issue
9
pages
1287 - 1288
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000240353100028
  • pmid:16956839
  • scopus:33748782773
ISSN
1592-8721
language
English
LU publication?
yes
id
03de4f16-4961-4d57-bb67-216411318133 (old id 394180)
alternative location
http://www.haematologica.org/cgi/content/abstract/91/9/1287
date added to LUP
2016-04-01 16:14:11
date last changed
2021-02-17 04:23:11
@article{03de4f16-4961-4d57-bb67-216411318133,
  abstract     = {AML/GAS7, resulting from t(11;17)(q23;p13), has been reported in one case of treatment-related acute myeloid leukemia (AML). We present a de novo case of t(11;17)-positive pediatric acute lymphoblastic leukemia. Fluorescent in situ hybridization and reverse transcriptase polymerase chain reaction analyses revealed an MLL/GAS7 chimera identical to the one previously described in AML. The molecular genetic features of MLL/GAS7 and the clinical impact of t(11;17) are discussed.},
  author       = {Panagopoulos, Ioannis and Lilljebjörn, Henrik and Strömbeck, Bodil and Hjorth, Lars and Olofsson, Tor and Johansson, Bertil},
  issn         = {1592-8721},
  language     = {eng},
  number       = {9},
  pages        = {1287--1288},
  publisher    = {Ferrata Storti Foundation},
  series       = {Haematologica},
  title        = {MLL/GAS7 fusion in a pediatric case of t(11;17)(q23;p13)-positive precursor B-cell acute lymphoblastic leukemia},
  url          = {http://www.haematologica.org/cgi/content/abstract/91/9/1287},
  volume       = {91},
  year         = {2006},
}