The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1 : An IMI DIRECT Study
(2024) In Journal of Clinical Endocrinology and Metabolism 109(9). p.1697-1707- Abstract
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased... (More)
Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes. Conclusion: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.
(Less)
- author
- organization
- publishing date
- 2024-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- cardiometabolic markers, diet, GLP-1, incretin, insulin resistance, liver fat, nutrition, obesity, prediabetes, type 2 diabetes
- in
- Journal of Clinical Endocrinology and Metabolism
- volume
- 109
- issue
- 9
- pages
- 1697 - 1707
- publisher
- Oxford University Press
- external identifiers
-
- pmid:38686701
- scopus:85201230805
- ISSN
- 0021-972X
- DOI
- 10.1210/clinem/dgae119
- language
- English
- LU publication?
- yes
- id
- 3995fea3-30e2-4db7-92bc-1e61320b1e92
- date added to LUP
- 2024-12-20 10:56:59
- date last changed
- 2025-07-05 03:16:04
@article{3995fea3-30e2-4db7-92bc-1e61320b1e92,
abstract = {{<p>Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on Patient Stratification (DIRECT) cohorts, cohort 1 (n = 2127) individuals at risk of diabetes; cohort 2 (n = 789) individuals with new-onset T2D. Results: Our multiple regression analysis reveals that fasting total GLP-1 is associated with an insulin-resistant phenotype and observe a strong independent relationship with male sex, increased adiposity, and liver fat, particularly in the prediabetes population. In contrast, we showed that incremental GLP-1 decreases with worsening glycemia, higher adiposity, liver fat, male sex, and reduced insulin sensitivity in the prediabetes cohort. Higher fasting total GLP-1 was associated with a low intake of wholegrain, fruit, and vegetables in people with prediabetes, and with a high intake of red meat and alcohol in people with diabetes. Conclusion: These studies provide novel insights into the association between fasting and incremental GLP-1, metabolic traits of diabetes and obesity, and dietary intake, and raise intriguing questions regarding the relevance of fasting GLP-1 in the pathophysiology T2D.</p>}},
author = {{Eriksen, Rebeca and White, Margaret C. and Dawed, Adem Y. and Perez, Isabel Garcia and Posma, Joram M. and Haid, Mark and Sharma, Sapna and Prehn, Cornelia and Thomas, E. Louise and Koivula, Robert W. and Bizzotto, Roberto and Mari, Andrea and Giordano, Giuseppe N. and Pavo, Imre and Schwenk, Jochen M. and De Masi, Federico and Tsirigos, Konstantinos D. and Brunak, Søren and Viñuela, Ana and Mahajan, Anubha and McDonald, Timothy J. and Kokkola, Tarja and Rutters, Femke and Beulens, Joline and Muilwijk, Mirthe and Blom, Marieke and Elders, Petra and Hansen, Tue H. and Fernandez-Tajes, Juan and Jones, Angus and Jennison, Chris and Walker, Mark and McCarthy, Mark I. and Pedersen, Oluf and Ruetten, Hartmut and Forgie, Ian and Holst, Jens J. and Thomsen, Henrik S. and Ridderstråle, Martin and Bell, Jimmy D. and Adamski, Jerzy and Franks, Paul W. and Hansen, Torben and Holmes, Elaine and Frost, Gary and Pearson, Ewan R.}},
issn = {{0021-972X}},
keywords = {{cardiometabolic markers; diet; GLP-1; incretin; insulin resistance; liver fat; nutrition; obesity; prediabetes; type 2 diabetes}},
language = {{eng}},
number = {{9}},
pages = {{1697--1707}},
publisher = {{Oxford University Press}},
series = {{Journal of Clinical Endocrinology and Metabolism}},
title = {{The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1 : An IMI DIRECT Study}},
url = {{http://dx.doi.org/10.1210/clinem/dgae119}},
doi = {{10.1210/clinem/dgae119}},
volume = {{109}},
year = {{2024}},
}