Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.
Singh, Kalpana LU ; Nordström, Therése LU ; Mörgelin, Matthias LU ; Brant, Marta LU ; Cardell, Lars-Olaf LU and Riesbeck, Kristian LU
(2014)
In Journal of Infectious Diseases
209(9).
p.1418-1428
- Abstract
- Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in... (More)
- Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4179561
- author
- Singh, Kalpana
LU
; Nordström, Therése
LU
; Mörgelin, Matthias
LU
; Brant, Marta
LU
; Cardell, Lars-Olaf
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2014
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Infectious Diseases
- volume
- 209
- issue
- 9
- pages
- 1418 - 1428
- publisher
- Oxford University Press
- external identifiers
-
- pmid:24218509
- wos:000334689700014
- scopus:84898891984
- ISSN
- 1537-6613
- DOI
- 10.1093/infdis/jit593
- language
- English
- LU publication?
- yes
- id
- 39c88de8-47ef-4fbd-8881-075f4cc35a5a (old id 4179561)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24218509?dopt=Abstract
- date added to LUP
- 2016-04-01 10:00:53
- date last changed
- 2022-02-02 05:32:29
@article{39c88de8-47ef-4fbd-8881-075f4cc35a5a,
abstract = {{Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.}},
author = {{Singh, Kalpana and Nordström, Therése and Mörgelin, Matthias and Brant, Marta and Cardell, Lars-Olaf and Riesbeck, Kristian}},
issn = {{1537-6613}},
language = {{eng}},
number = {{9}},
pages = {{1418--1428}},
publisher = {{Oxford University Press}},
series = {{Journal of Infectious Diseases}},
title = {{Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.}},
url = {{http://dx.doi.org/10.1093/infdis/jit593}},
doi = {{10.1093/infdis/jit593}},
volume = {{209}},
year = {{2014}},
}