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Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition

Aleksandrova, Krasimira ; Pischon, Tobias ; Buijsse, Brian ; May, Anne M. ; Peeters, Petra H. ; Bueno-de-Mesquita, H. Bas ; Jenab, Mazda ; Fedirko, Veronika ; Dahm, Christina C. and Siersema, Peter D. , et al. (2013) In European Journal of Cancer 49(16). p.3526-3536
Abstract
Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment... (More)
Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P-interaction = 0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95% CI 1.14-2.91, P-interaction = 0.02). Results were not different in men and women (P-interaction = 0.81). Conclusion(s): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention. (C) 2013 Elsevier Ltd. All rights reserved. (Less)
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publication status
published
subject
keywords
Body weight change, Colorectal neoplasms, Abdominal obesity, Cancer, prevention
in
European Journal of Cancer
volume
49
issue
16
pages
3526 - 3536
publisher
IFAC & Elsevier Ltd.
external identifiers
  • wos:000325425800016
  • scopus:84885180930
  • pmid:23867126
ISSN
1879-0852
DOI
10.1016/j.ejca.2013.06.021
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Internal Medicine Research Unit (013242520), Pathology, (Lund) (013030000)
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3a9a621b-fafb-4982-b5a9-a9b087a7a87c (old id 4160259)
date added to LUP
2016-04-01 11:00:58
date last changed
2020-01-12 06:39:36
@article{3a9a621b-fafb-4982-b5a9-a9b087a7a87c,
  abstract     = {Aim: Weight change during adult life may reflect metabolic changes and influence colorectal cancer (CRC) development, but such role is not well established. We aimed to explore the association between adult weight change (from age 20 to 50) and CRC risk. In particular, we investigated differences according to colon and rectal cancer, sex and measures of attained adiposity. Methods: We included 201,696 participants from six participating countries in the European Prospective Investigation into Cancer and Nutrition (1992-2010). During a mean follow-up of 11.2 years 2384 (1194 in men and 1190 in women) incident CRC cases occurred. Cox proportional hazard models adjusted for body mass index at age 20 and lifestyle factors at study recruitment were used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After multivariable adjustment, each kg of weight gained annually from age 20 to 50 was associated with a 60% higher risk of colon cancer (95% CI 1.20-2.09), but not rectal cancer (HR 1.13, 95% CI 0.79-1.62, P-interaction = 0.04). The higher risk of colon cancer was restricted to people with high attained waist circumference at age 50 (HR 1.82, 95% CI 1.14-2.91, P-interaction = 0.02). Results were not different in men and women (P-interaction = 0.81). Conclusion(s): Adult weight gain, as reflected by attained abdominal obesity at age 50, increases colon cancer risk in both men and women. These data underline the importance of weight management and metabolic health maintenance in early adult life years for colon cancer prevention. (C) 2013 Elsevier Ltd. All rights reserved.},
  author       = {Aleksandrova, Krasimira and Pischon, Tobias and Buijsse, Brian and May, Anne M. and Peeters, Petra H. and Bueno-de-Mesquita, H. Bas and Jenab, Mazda and Fedirko, Veronika and Dahm, Christina C. and Siersema, Peter D. and Freisling, Heinz and Ferrari, Pietro and Overvad, Kim and Tjonneland, Anne and Trichopoulou, Antonia and Lagiou, Pagona and Naska, Androniki and Pala, Valeria and Mattiello, Amalia and Ohlsson, Bodil and Jirström, Karin and Key, Timothy J. and Khaw, Kay-Tee and Riboli, Elio and Boeing, Heiner},
  issn         = {1879-0852},
  language     = {eng},
  number       = {16},
  pages        = {3526--3536},
  publisher    = {IFAC & Elsevier Ltd.},
  series       = {European Journal of Cancer},
  title        = {Adult weight change and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1016/j.ejca.2013.06.021},
  doi          = {10.1016/j.ejca.2013.06.021},
  volume       = {49},
  year         = {2013},
}