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Maternal food consumption during late pregnancy and offspring risk of islet autoimmunity and type 1 diabetes

Johnson, Randi K. ; Tamura, Roy ; Frank, Nicole ; Uusitalo, Ulla ; Yang, Jimin ; Niinistö, Sari ; Andrén Aronsson, Carin LU orcid ; Ziegler, Anette G. ; Hagopian, William and Rewers, Marian , et al. (2021) In Diabetologia 64(7). p.1604-1612
Abstract

Aims/hypothesis: We aimed to investigate the association between maternal consumption of gluten-containing foods and other selected foods during late pregnancy and offspring risk of islet autoimmunity (IA) and type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: The TEDDY study recruited children at high genetic risk for type 1 diabetes at birth, and prospectively follows them for the development of IA and type 1 diabetes (n = 8556). A questionnaire on the mother’s diet in late pregnancy was completed by 3–4 months postpartum. The maternal daily intake was estimated from a food frequency questionnaire for eight food groups: gluten-containing foods, non-gluten cereals, fresh milk, sour milk,... (More)

Aims/hypothesis: We aimed to investigate the association between maternal consumption of gluten-containing foods and other selected foods during late pregnancy and offspring risk of islet autoimmunity (IA) and type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: The TEDDY study recruited children at high genetic risk for type 1 diabetes at birth, and prospectively follows them for the development of IA and type 1 diabetes (n = 8556). A questionnaire on the mother’s diet in late pregnancy was completed by 3–4 months postpartum. The maternal daily intake was estimated from a food frequency questionnaire for eight food groups: gluten-containing foods, non-gluten cereals, fresh milk, sour milk, cheese products, soy products, lean/medium-fat fish and fatty fish. For each food, we described the distribution of maternal intake among the four participating countries in the TEDDY study and tested the association of tertile of maternal food consumption with risk of IA and type 1 diabetes using forward selection time-to-event Cox regression. Results: By 28 February 2019, 791 cases of IA and 328 cases of type 1 diabetes developed in TEDDY. There was no association between maternal late-pregnancy consumption of gluten-containing foods or any of the other selected foods and risk of IA, type 1 diabetes, insulin autoantibody-first IA or GAD autoantibody-first IA (all p ≥ 0.01). Maternal gluten-containing food consumption in late pregnancy was higher in Sweden (242 g/day), Germany (247 g/day) and Finland (221 g/day) than in the USA (199 g/day) (pairwise p < 0.05). Conclusions/interpretation: Maternal food consumption during late pregnancy was not associated with offspring risk for IA or type 1 diabetes. Trial registration: ClinicalTrials.gov NCT00279318. Graphical abstract: [Figure not available: see fulltext.]

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type
Contribution to journal
publication status
published
subject
keywords
Autoimmunity, Gluten, Maternal diet, Pregnancy, Type 1 diabetes
in
Diabetologia
volume
64
issue
7
pages
9 pages
publisher
Springer
external identifiers
  • pmid:33783586
  • scopus:85103945244
ISSN
0012-186X
DOI
10.1007/s00125-021-05446-y
language
English
LU publication?
yes
id
3ab4573f-d89f-460d-8a3f-c12cbc5b5f72
date added to LUP
2021-04-21 11:18:14
date last changed
2022-05-24 06:02:52
@article{3ab4573f-d89f-460d-8a3f-c12cbc5b5f72,
  abstract     = {{<p>Aims/hypothesis: We aimed to investigate the association between maternal consumption of gluten-containing foods and other selected foods during late pregnancy and offspring risk of islet autoimmunity (IA) and type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study. Methods: The TEDDY study recruited children at high genetic risk for type 1 diabetes at birth, and prospectively follows them for the development of IA and type 1 diabetes (n = 8556). A questionnaire on the mother’s diet in late pregnancy was completed by 3–4 months postpartum. The maternal daily intake was estimated from a food frequency questionnaire for eight food groups: gluten-containing foods, non-gluten cereals, fresh milk, sour milk, cheese products, soy products, lean/medium-fat fish and fatty fish. For each food, we described the distribution of maternal intake among the four participating countries in the TEDDY study and tested the association of tertile of maternal food consumption with risk of IA and type 1 diabetes using forward selection time-to-event Cox regression. Results: By 28 February 2019, 791 cases of IA and 328 cases of type 1 diabetes developed in TEDDY. There was no association between maternal late-pregnancy consumption of gluten-containing foods or any of the other selected foods and risk of IA, type 1 diabetes, insulin autoantibody-first IA or GAD autoantibody-first IA (all p ≥ 0.01). Maternal gluten-containing food consumption in late pregnancy was higher in Sweden (242 g/day), Germany (247 g/day) and Finland (221 g/day) than in the USA (199 g/day) (pairwise p &lt; 0.05). Conclusions/interpretation: Maternal food consumption during late pregnancy was not associated with offspring risk for IA or type 1 diabetes. Trial registration: ClinicalTrials.gov NCT00279318. Graphical abstract: [Figure not available: see fulltext.]</p>}},
  author       = {{Johnson, Randi K. and Tamura, Roy and Frank, Nicole and Uusitalo, Ulla and Yang, Jimin and Niinistö, Sari and Andrén Aronsson, Carin and Ziegler, Anette G. and Hagopian, William and Rewers, Marian and Toppari, Jorma and Akolkar, Beena and Krischer, Jeffrey and Virtanen, Suvi M. and Norris, Jill M.}},
  issn         = {{0012-186X}},
  keywords     = {{Autoimmunity; Gluten; Maternal diet; Pregnancy; Type 1 diabetes}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{7}},
  pages        = {{1604--1612}},
  publisher    = {{Springer}},
  series       = {{Diabetologia}},
  title        = {{Maternal food consumption during late pregnancy and offspring risk of islet autoimmunity and type 1 diabetes}},
  url          = {{http://dx.doi.org/10.1007/s00125-021-05446-y}},
  doi          = {{10.1007/s00125-021-05446-y}},
  volume       = {{64}},
  year         = {{2021}},
}