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Hypophyseal tumor and gynecomastia preceding bilateral breast cancer development in a man

Olsson, Hakan LU ; Alm, Per LU ; Kristoffersson, Ulf LU and Landin‐Olsson, Mona LU (1984) In Cancer 53(9). p.1974-1977
Abstract

The case is reported of a 48‐year‐old man who, 26 years after treatment for a hypophyseal tumor and 11 years after the onset of bilateral gynecomastia, developed cancer of the left breast. Ten years after the first breast cancer operation a new cancer developed in his right breast. Hormonal investigation at the time of the second breast cancer operation revealed a low S‐FSH and a relative estrogen excess compared to testosterone. Values of thyroid and adrenal hormones were essentially normal, while P‐prolactin was elevated. Stimulatory tests of the hypophyseal function were in accordance with a partial hypophyseal insufficiency affecting the hypophyseal‐gonadal axis. Also, a weak elevation of S‐HGH was noted by an insulin tolerance... (More)

The case is reported of a 48‐year‐old man who, 26 years after treatment for a hypophyseal tumor and 11 years after the onset of bilateral gynecomastia, developed cancer of the left breast. Ten years after the first breast cancer operation a new cancer developed in his right breast. Hormonal investigation at the time of the second breast cancer operation revealed a low S‐FSH and a relative estrogen excess compared to testosterone. Values of thyroid and adrenal hormones were essentially normal, while P‐prolactin was elevated. Stimulatory tests of the hypophyseal function were in accordance with a partial hypophyseal insufficiency affecting the hypophyseal‐gonadal axis. Also, a weak elevation of S‐HGH was noted by an insulin tolerance test. Immunohistochemical analysis of the pituitary tumor 36 years later showed that the tumor could be classified as a prolactinoma. Cytogenetic analysis revealed a normal male chromosome karyotype.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cancer
volume
53
issue
9
pages
1974 - 1977
publisher
John Wiley & Sons
external identifiers
  • scopus:0021164773
ISSN
0008-543X
DOI
10.1002/1097-0142(19840501)53:9<1974::AID-CNCR2820530928>3.0.CO;2-G
language
English
LU publication?
yes
id
3b0c9265-d403-4742-a36c-0c6d3aa2f532
date added to LUP
2018-12-17 10:45:37
date last changed
2019-01-06 14:20:06
@article{3b0c9265-d403-4742-a36c-0c6d3aa2f532,
  abstract     = {<p>The case is reported of a 48‐year‐old man who, 26 years after treatment for a hypophyseal tumor and 11 years after the onset of bilateral gynecomastia, developed cancer of the left breast. Ten years after the first breast cancer operation a new cancer developed in his right breast. Hormonal investigation at the time of the second breast cancer operation revealed a low S‐FSH and a relative estrogen excess compared to testosterone. Values of thyroid and adrenal hormones were essentially normal, while P‐prolactin was elevated. Stimulatory tests of the hypophyseal function were in accordance with a partial hypophyseal insufficiency affecting the hypophyseal‐gonadal axis. Also, a weak elevation of S‐HGH was noted by an insulin tolerance test. Immunohistochemical analysis of the pituitary tumor 36 years later showed that the tumor could be classified as a prolactinoma. Cytogenetic analysis revealed a normal male chromosome karyotype.</p>},
  author       = {Olsson, Hakan and Alm, Per and Kristoffersson, Ulf and Landin‐Olsson, Mona},
  issn         = {0008-543X},
  language     = {eng},
  month        = {01},
  number       = {9},
  pages        = {1974--1977},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Hypophyseal tumor and gynecomastia preceding bilateral breast cancer development in a man},
  url          = {http://dx.doi.org/10.1002/1097-0142(19840501)53:9<1974::AID-CNCR2820530928>3.0.CO;2-G},
  volume       = {53},
  year         = {1984},
}