Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance
(2024) In Blood Cancer Journal 14. p.1-12- Abstract
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that collectively contribute to MGUS risk. To test this hypothesis, we used data from our previous GWAS on 992 MGUS cases and 2910 controls from three European populations. We identified 23 haplotypes that were associated with the risk of MGUS at the genome-wide significance level (p < 5 × 10−8) and showed consistent results among... (More)
Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that collectively contribute to MGUS risk. To test this hypothesis, we used data from our previous GWAS on 992 MGUS cases and 2910 controls from three European populations. We identified 23 haplotypes that were associated with the risk of MGUS at the genome-wide significance level (p < 5 × 10−8) and showed consistent results among all three populations. In 10 genomic regions, strong promoter, enhancer and regulatory element-related histone marks and their connections to target genes as well as genome segmentation data supported the importance of these regions in MGUS susceptibility. Several associated haplotypes affected pathways important for MM cell survival such as ubiquitin-proteasome system (RNF186, OTUD3), PI3K/AKT/mTOR (HINT3), innate immunity (SEC14L1, ZBP1), cell death regulation (BID) and NOTCH signaling (RBPJ). These pathways are important current therapeutic targets for MM, which may highlight the advantage of the haplotype approach homing to functional units.
(Less)
- author
- organization
- publishing date
- 2024
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Blood Cancer Journal
- volume
- 14
- article number
- 140
- pages
- 1 - 12
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:39164264
- scopus:85201603885
- ISSN
- 2044-5385
- DOI
- 10.1038/s41408-024-01121-8
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2024.
- id
- 3b130e65-a24a-46ea-820f-9835ab39babc
- date added to LUP
- 2024-09-08 16:15:18
- date last changed
- 2024-09-10 02:56:24
@article{3b130e65-a24a-46ea-820f-9835ab39babc, abstract = {{<p>Genome-wide association studies (GWASs) based on common single nucleotide polymorphisms (SNPs) have identified several loci associated with the risk of monoclonal gammopathy of unknown significance (MGUS), a precursor condition for multiple myeloma (MM). We hypothesized that analyzing haplotypes might be more useful than analyzing individual SNPs, as it could identify functional chromosomal units that collectively contribute to MGUS risk. To test this hypothesis, we used data from our previous GWAS on 992 MGUS cases and 2910 controls from three European populations. We identified 23 haplotypes that were associated with the risk of MGUS at the genome-wide significance level (p < 5 × 10<sup>−8</sup>) and showed consistent results among all three populations. In 10 genomic regions, strong promoter, enhancer and regulatory element-related histone marks and their connections to target genes as well as genome segmentation data supported the importance of these regions in MGUS susceptibility. Several associated haplotypes affected pathways important for MM cell survival such as ubiquitin-proteasome system (RNF186, OTUD3), PI3K/AKT/mTOR (HINT3), innate immunity (SEC14L1, ZBP1), cell death regulation (BID) and NOTCH signaling (RBPJ). These pathways are important current therapeutic targets for MM, which may highlight the advantage of the haplotype approach homing to functional units.</p>}}, author = {{Thomsen, Hauke and Chattopadhyay, Subhayan and Weinhold, Niels and Vodicka, Pavel and Vodickova, Ludmila and Hoffmann, Per and Nöthen, Markus M. and Jöckel, Karl Heinz and Schmidt, Börge and Hajek, Roman and Hallmans, Göran and Pettersson-Kymmer, Ulrika and Späth, Florentin and Goldschmidt, Hartmut and Hemminki, Kari and Försti, Asta}}, issn = {{2044-5385}}, language = {{eng}}, pages = {{1--12}}, publisher = {{Nature Publishing Group}}, series = {{Blood Cancer Journal}}, title = {{Haplotype analysis identifies functional elements in monoclonal gammopathy of unknown significance}}, url = {{http://dx.doi.org/10.1038/s41408-024-01121-8}}, doi = {{10.1038/s41408-024-01121-8}}, volume = {{14}}, year = {{2024}}, }