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Nerve repair and axonal transport : Outgrowth delay and regeneration rate after transection and repair of rabbit hypoglossal nerve

Danielsen, N LU ; Lundborg, G LU and Frizell, M (1986) In Brain Research 376(1). p.32-125
Abstract

The axonal transport and distribution of the fast phase of [3H]leucine-labeled proteins were used to monitor the outgrowth delay and regeneration rate in rabbit hypoglossal nerves 5-21 days after crush or transection. The transected nerves were repaired with mesothelial chambers or epineurial sutures. Radiolabeled proteins were transported into regenerating axons in the distal nerve segment after an initial delay of 2.5 days for crushed nerves and after a delay (initial and scar delays) of 4.8 and 5.7 days for sutured and mesothelial chamber-reconnected nerves, respectively. Regeneration rate was 3.5 mm/day after a crush and 2 mm/day after a transection with either type of repair. Total radioactivity was greater in both crushed and... (More)

The axonal transport and distribution of the fast phase of [3H]leucine-labeled proteins were used to monitor the outgrowth delay and regeneration rate in rabbit hypoglossal nerves 5-21 days after crush or transection. The transected nerves were repaired with mesothelial chambers or epineurial sutures. Radiolabeled proteins were transported into regenerating axons in the distal nerve segment after an initial delay of 2.5 days for crushed nerves and after a delay (initial and scar delays) of 4.8 and 5.7 days for sutured and mesothelial chamber-reconnected nerves, respectively. Regeneration rate was 3.5 mm/day after a crush and 2 mm/day after a transection with either type of repair. Total radioactivity was greater in both crushed and repaired nerves than in their contralateral controls. Transported radioactivity accumulated at the site of the lesions. This accumulation was greater and persisted longer in repaired nerves than in crushed ones. The difference in regenerative response after different types of trauma with respect to changes in axonal transport is emphasized.

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author
publishing date
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Contribution to journal
publication status
published
keywords
Animals, Axons, Biological Transport, Denervation, Female, Hypoglossal Nerve, Leucine, Male, Nerve Crush, Nerve Regeneration, Rabbits, Time Factors, Tissue Distribution, Tritium, Journal Article, Research Support, Non-U.S. Gov't
in
Brain Research
volume
376
issue
1
pages
8 pages
publisher
Elsevier
external identifiers
  • scopus:0022473116
ISSN
0006-8993
DOI
10.1016/0006-8993(86)90906-6
language
English
LU publication?
no
id
3b5a1838-c25d-4c4f-9ac0-76f10840f619
date added to LUP
2017-10-13 14:11:30
date last changed
2017-10-16 09:24:21
@article{3b5a1838-c25d-4c4f-9ac0-76f10840f619,
  abstract     = {<p>The axonal transport and distribution of the fast phase of [3H]leucine-labeled proteins were used to monitor the outgrowth delay and regeneration rate in rabbit hypoglossal nerves 5-21 days after crush or transection. The transected nerves were repaired with mesothelial chambers or epineurial sutures. Radiolabeled proteins were transported into regenerating axons in the distal nerve segment after an initial delay of 2.5 days for crushed nerves and after a delay (initial and scar delays) of 4.8 and 5.7 days for sutured and mesothelial chamber-reconnected nerves, respectively. Regeneration rate was 3.5 mm/day after a crush and 2 mm/day after a transection with either type of repair. Total radioactivity was greater in both crushed and repaired nerves than in their contralateral controls. Transported radioactivity accumulated at the site of the lesions. This accumulation was greater and persisted longer in repaired nerves than in crushed ones. The difference in regenerative response after different types of trauma with respect to changes in axonal transport is emphasized.</p>},
  author       = {Danielsen, N and Lundborg, G and Frizell, M},
  issn         = {0006-8993},
  keyword      = {Animals,Axons,Biological Transport,Denervation,Female,Hypoglossal Nerve,Leucine,Male,Nerve Crush,Nerve Regeneration,Rabbits,Time Factors,Tissue Distribution,Tritium,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  month        = {06},
  number       = {1},
  pages        = {32--125},
  publisher    = {Elsevier},
  series       = {Brain Research},
  title        = {Nerve repair and axonal transport : Outgrowth delay and regeneration rate after transection and repair of rabbit hypoglossal nerve},
  url          = {http://dx.doi.org/10.1016/0006-8993(86)90906-6},
  volume       = {376},
  year         = {1986},
}