Dietary fiber in bilberry ameliorates pre-obesity events in rats by regulating lipid depot, cecal short-chain fatty acid formation and microbiota composition
(2019) In Nutrients 11(6).- Abstract
- Obesity is linked to non-alcoholic fatty liver disease and risk factors associated to metabolic syndrome. Bilberry (Vaccinium myrtillus) that contains easily fermentable fiber may strengthen the intestinal barrier function, attenuate inflammation and modulate gut microbiota composition, thereby prevent obesity development. In the current study, liver lipid metabolism, fat depot, cecal and serum short-chain fatty acids (SCFAs) and gut microbiome were evaluated in rats fed bilberries in a high-fat (HFD + BB) or low-fat (LFD + BB) setting for 8 weeks and compared with diets containing equal amount of fiber resistant to fermentation (cellulose, HFD and LFD). HFD fed rats did not obtain an obese phenotype but underwent pre-obesity events... (More)
- Obesity is linked to non-alcoholic fatty liver disease and risk factors associated to metabolic syndrome. Bilberry (Vaccinium myrtillus) that contains easily fermentable fiber may strengthen the intestinal barrier function, attenuate inflammation and modulate gut microbiota composition, thereby prevent obesity development. In the current study, liver lipid metabolism, fat depot, cecal and serum short-chain fatty acids (SCFAs) and gut microbiome were evaluated in rats fed bilberries in a high-fat (HFD + BB) or low-fat (LFD + BB) setting for 8 weeks and compared with diets containing equal amount of fiber resistant to fermentation (cellulose, HFD and LFD). HFD fed rats did not obtain an obese phenotype but underwent pre-obesity events including increased liver index, lipid accumulation and increased serum cholesterol levels. This was linked to shifts of cecal bacterial community and reduction of major SCFAs. Bilberry inclusion improved liver metabolism and serum lipid levels. Bilberry inclusion under either LFD or HFD, maintained microbiota homeostasis, stimulated interscapular-brown adipose tissue depot associated with increased mRNA expression of uncoupling protein-1; enhanced SCFAs in the cecum and circulation; and promoted butyric acid and butyrate-producing bacteria. These findings suggest that bilberry may serve as a preventative dietary measure to optimize microbiome and associated lipid metabolism during or prior to HFD (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3b883bdb-98c1-4930-8a0b-b8876254f6e2
- author
- Liu, Hao-Yu ; Waldén, Tomas B. ; Cai, Demin ; Ahl, David ; Bertilsson, Stefan ; Philipson, Mia ; Nyman, Margareta LU and Holm, Lena
- organization
- publishing date
- 2019-06-15
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nutrients
- volume
- 11
- issue
- 6
- article number
- 1350
- pages
- 17 pages
- publisher
- MDPI AG
- external identifiers
-
- scopus:85068371311
- pmid:31208043
- ISSN
- 2072-6643
- DOI
- 10.3390/nu11061350
- language
- English
- LU publication?
- yes
- id
- 3b883bdb-98c1-4930-8a0b-b8876254f6e2
- date added to LUP
- 2019-06-17 17:08:56
- date last changed
- 2023-12-17 22:30:59
@article{3b883bdb-98c1-4930-8a0b-b8876254f6e2, abstract = {{Obesity is linked to non-alcoholic fatty liver disease and risk factors associated to metabolic syndrome. Bilberry (Vaccinium myrtillus) that contains easily fermentable fiber may strengthen the intestinal barrier function, attenuate inflammation and modulate gut microbiota composition, thereby prevent obesity development. In the current study, liver lipid metabolism, fat depot, cecal and serum short-chain fatty acids (SCFAs) and gut microbiome were evaluated in rats fed bilberries in a high-fat (HFD + BB) or low-fat (LFD + BB) setting for 8 weeks and compared with diets containing equal amount of fiber resistant to fermentation (cellulose, HFD and LFD). HFD fed rats did not obtain an obese phenotype but underwent pre-obesity events including increased liver index, lipid accumulation and increased serum cholesterol levels. This was linked to shifts of cecal bacterial community and reduction of major SCFAs. Bilberry inclusion improved liver metabolism and serum lipid levels. Bilberry inclusion under either LFD or HFD, maintained microbiota homeostasis, stimulated interscapular-brown adipose tissue depot associated with increased mRNA expression of uncoupling protein-1; enhanced SCFAs in the cecum and circulation; and promoted butyric acid and butyrate-producing bacteria. These findings suggest that bilberry may serve as a preventative dietary measure to optimize microbiome and associated lipid metabolism during or prior to HFD}}, author = {{Liu, Hao-Yu and Waldén, Tomas B. and Cai, Demin and Ahl, David and Bertilsson, Stefan and Philipson, Mia and Nyman, Margareta and Holm, Lena}}, issn = {{2072-6643}}, language = {{eng}}, month = {{06}}, number = {{6}}, publisher = {{MDPI AG}}, series = {{Nutrients}}, title = {{Dietary fiber in bilberry ameliorates pre-obesity events in rats by regulating lipid depot, cecal short-chain fatty acid formation and microbiota composition}}, url = {{http://dx.doi.org/10.3390/nu11061350}}, doi = {{10.3390/nu11061350}}, volume = {{11}}, year = {{2019}}, }