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Association of arterial stiffness with coronary artery calcium score in the general-population : the Swedish CArdioPulmonary bioImage study

Muhammad, Iram Faqir LU ; Engvall, Jan E ; Persson, Margaretha LU orcid ; Borné, Yan LU ; Nilsson, Peter M LU ; Östgren, Carl Johan LU and Engström, Gunnar LU (2022) In Journal of Hypertension 40(5). p.933-939
Abstract

OBJECTIVES: Coronary artery calcium score (CACS) is a marker of subclinical atherosclerosis. However, there is little data related to the association between arterial stiffness and CACS in the general population. The aim of this study was to explore the association between carotid femoral-pulse wave velocity (c-f PWV), a widely accepted marker of arterial stiffness, and CACS.

METHODS: Participants with complete measurements on c-f PWV, CACS and confounding variables from the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort were included in the final study population (n = 8725). CACS was divided into three categories (≤10, >10 and ≤100, and >100) and multinomial logistic regression was performed to explore the... (More)

OBJECTIVES: Coronary artery calcium score (CACS) is a marker of subclinical atherosclerosis. However, there is little data related to the association between arterial stiffness and CACS in the general population. The aim of this study was to explore the association between carotid femoral-pulse wave velocity (c-f PWV), a widely accepted marker of arterial stiffness, and CACS.

METHODS: Participants with complete measurements on c-f PWV, CACS and confounding variables from the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort were included in the final study population (n = 8725). CACS was divided into three categories (≤10, >10 and ≤100, and >100) and multinomial logistic regression was performed to explore the association between these categories of CACS and quartiles of c-f PWV, and for per one standard deviation (SD) increment of c-f PWV.

RESULTS: CACS ≤10, >10 and ≤100, and >100 were present in 69.3, 17.8 and 12.9% of the study population, respectively. The odds ratio (OR) for CACS >100 for the fourth quartile (Q4) of c-f PWV vs. Q1 (reference category) was 1.62 (95% confidence interval [CI] 1.25-2.12) after adjustments. One standard deviation increase in c-f PWV was independently associated with a higher odds of having a CACS category >100 (OR: 1.25, 95% CI 1.14-1.36) in the final multivariable model.

CONCLUSION: c-f PWV is positively associated with increased risk of higher CACS, and can be valuable in identifying individuals at risk for sub-clinical atherosclerosis.

VIDEO ABSTRACT: http://links.lww.com/HJH/B863.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Hypertension
volume
40
issue
5
pages
933 - 939
publisher
Lippincott Williams & Wilkins
external identifiers
  • pmid:35142741
  • scopus:85129996678
ISSN
1473-5598
DOI
10.1097/HJH.0000000000003096
language
English
LU publication?
yes
additional info
Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.
id
3bc1f833-a0c4-409a-af3e-6f610418f8db
date added to LUP
2022-02-14 13:18:38
date last changed
2024-09-20 02:17:13
@article{3bc1f833-a0c4-409a-af3e-6f610418f8db,
  abstract     = {{<p>OBJECTIVES: Coronary artery calcium score (CACS) is a marker of subclinical atherosclerosis. However, there is little data related to the association between arterial stiffness and CACS in the general population. The aim of this study was to explore the association between carotid femoral-pulse wave velocity (c-f PWV), a widely accepted marker of arterial stiffness, and CACS.</p><p>METHODS: Participants with complete measurements on c-f PWV, CACS and confounding variables from the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort were included in the final study population (n = 8725). CACS was divided into three categories (≤10, &gt;10 and ≤100, and &gt;100) and multinomial logistic regression was performed to explore the association between these categories of CACS and quartiles of c-f PWV, and for per one standard deviation (SD) increment of c-f PWV.</p><p>RESULTS: CACS ≤10, &gt;10 and ≤100, and &gt;100 were present in 69.3, 17.8 and 12.9% of the study population, respectively. The odds ratio (OR) for CACS &gt;100 for the fourth quartile (Q4) of c-f PWV vs. Q1 (reference category) was 1.62 (95% confidence interval [CI] 1.25-2.12) after adjustments. One standard deviation increase in c-f PWV was independently associated with a higher odds of having a CACS category &gt;100 (OR: 1.25, 95% CI 1.14-1.36) in the final multivariable model.</p><p>CONCLUSION: c-f PWV is positively associated with increased risk of higher CACS, and can be valuable in identifying individuals at risk for sub-clinical atherosclerosis.</p><p>VIDEO ABSTRACT: http://links.lww.com/HJH/B863.</p>}},
  author       = {{Muhammad, Iram Faqir and Engvall, Jan E and Persson, Margaretha and Borné, Yan and Nilsson, Peter M and Östgren, Carl Johan and Engström, Gunnar}},
  issn         = {{1473-5598}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{933--939}},
  publisher    = {{Lippincott Williams & Wilkins}},
  series       = {{Journal of Hypertension}},
  title        = {{Association of arterial stiffness with coronary artery calcium score in the general-population : the Swedish CArdioPulmonary bioImage study}},
  url          = {{http://dx.doi.org/10.1097/HJH.0000000000003096}},
  doi          = {{10.1097/HJH.0000000000003096}},
  volume       = {{40}},
  year         = {{2022}},
}