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Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Steindorf, Karen ; Friedenreich, Christine ; Linseisen, Jakob ; Rohrmann, Sabine ; Rundle, Andrew ; Veglia, Fabrizio ; Vineis, Paolo ; Johnsen, Nina Fonns ; Tjonneland, Anne and Overvad, Kim , et al. (2006) In International Journal of Cancer 119(10). p.2389-2397
Abstract
Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we... (More)
Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. (c) 2006 Wiley-Liss, Inc. (Less)
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published
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keywords
physical activity, exercise, epidemiology, lung cancer, cohort study
in
International Journal of Cancer
volume
119
issue
10
pages
2389 - 2397
publisher
John Wiley & Sons
external identifiers
  • pmid:16894558
  • wos:000241222300020
  • scopus:33749608808
ISSN
0020-7136
DOI
10.1002/ijc.22125
language
English
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3be526f3-15c2-41d4-8be7-d7596bbe30f9 (old id 387992)
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2016-04-01 12:23:26
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@article{3be526f3-15c2-41d4-8be7-d7596bbe30f9,
  abstract     = {Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on recent recreational, household and occupational physical activity, smoking habits and diet was assessed at baseline between 1992 and 2000. Relative risks (RR) were estimated using Cox regression. During 6.3 years of follow-up we identified 607 men and 476 women with incident lung cancer. We did not observe an inverse association between recent occupational, recreational or household physical activity and lung cancer risk in either males or females. However, we found some reduction in lung cancer risk associated with sports in males (adjusted RR = 0.71; 95% confidence interval 0.50-0.98; highest tertile vs. inactive group), cycling (RR = 0.73; 0.54-0.99) in females and non-occupational vigorous physical activity. For occupational physical activity, lung cancer risk was increased for unemployed men (adjusted RR = 1.57; 1.20-2.05) and men with standing occupations (RR = 1.35; 1.02-1.79) compared with sitting professions. There was no evidence of heterogeneity of physical activity associations across countries, or across any of the considered cofactors. For some histologic subtypes suggestive sex-specific reductions, limited by subgroup sizes, were observed, especially with vigorous physical activity. In total, our study shows no consistent protective associations of physical activity with lung cancer risk. It can be assumed that the elevated risks found for occupational physical activity are not produced mechanistically by physical activity itself but rather reflect exposure to occupation-related lung cancer risk factors. (c) 2006 Wiley-Liss, Inc.},
  author       = {Steindorf, Karen and Friedenreich, Christine and Linseisen, Jakob and Rohrmann, Sabine and Rundle, Andrew and Veglia, Fabrizio and Vineis, Paolo and Johnsen, Nina Fonns and Tjonneland, Anne and Overvad, Kim and Raaschou-Nielsen, Ole and Clavel-Chapelon, Francoise and Boutron-Ruault, Marie-Christine and Schulz, Mandy and Boeing, Heiner and Trichopoulou, Antonia and Kalapothaki, Victoria and Koliva, Maria and Krogh, Vittorio and Palli, Domenico and Tumino, Rosario and Panico, Salvatore and Monninkhof, Evelyn and Peeters, Petra H. and Boshuizen, Hendriek C. and Bueno-de-Mesquita, H. Bas and Chirlaque, Maria-Dolores and Agudo, Antonio and Larranaga, Nerea and Quiros, Jose R. and Martinez, Carmen and Barricarte, Aurelio and Janzon, Lars and Berglund, Göran and Bingham, Sheila and Khaw, Kay-Tee and Key, Timothy J. and Norat, Teresa and Jenab, Mazda and Cust, Anne and Riboli, Elio},
  issn         = {0020-7136},
  language     = {eng},
  number       = {10},
  pages        = {2389--2397},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort},
  url          = {http://dx.doi.org/10.1002/ijc.22125},
  doi          = {10.1002/ijc.22125},
  volume       = {119},
  year         = {2006},
}