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Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study

Rasouli, B. ; Ahlqvist, E. LU ; Alfredsson, L. ; Andersson, T. ; Carlsson, P. O. ; Groop, L. LU ; Löfvenborg, J. E. ; Martinell, M. ; Rosengren, A. and Tuomi, T. LU orcid , et al. (2018) In Diabetes & Metabolism 44(4). p.354-360
Abstract

Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential... (More)

Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results: Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370). Conclusion: Our findings suggest that coffee consumption interacts with HLA to promote LADA.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmune diabetes, Coffee consumption, Gene–environmental interaction, LADA, Latent autoimmune diabetes in adults, Type 2 diabetes, ANDIS, diabetes, diabetics
in
Diabetes & Metabolism
volume
44
issue
4
pages
354 - 360
publisher
Elsevier Masson SAS
external identifiers
  • scopus:85047774491
  • pmid:29861145
ISSN
1262-3636
DOI
10.1016/j.diabet.2018.05.002
language
English
LU publication?
yes
id
3c133b4f-c686-4daa-9d34-e0895e069b76
date added to LUP
2018-06-15 14:07:11
date last changed
2023-11-17 20:31:02
@article{3c133b4f-c686-4daa-9d34-e0895e069b76,
  abstract     = {{<p>Aim: Coffee consumption is inversely related to risk of type 2 diabetes (T2D). In contrast, an increased risk of latent autoimmune diabetes in adults (LADA) has been reported in heavy coffee consumers, primarily in a subgroup with stronger autoimmune characteristics. Our study aimed to investigate whether coffee consumption interacts with HLA genotypes in relation to risk of LADA. Methods: This population-based study comprised incident cases of LADA (n = 484) and T2D (n = 1609), and also 885 healthy controls. Information on coffee consumption was collected by food frequency questionnaire. Odds ratios (ORs) with 95% CIs of diabetes were calculated and adjusted for age, gender, BMI, education level, smoking and alcohol intake. Potential interactions between coffee consumption and high-risk HLA genotypes were calculated by attributable proportion (AP) due to interaction. Results: Coffee intake was positively associated with LADA in carriers of high-risk HLA genotypes (OR: 1.14 per cup/day, 95% CI: 1.02–1.28), whereas no association was observed in non-carriers (OR: 1.04, 95% CI: 0.93–1.17). Subjects with both heavy coffee consumption (≥ 4 cups/day) and high-risk HLA genotypes had an OR of 5.74 (95% CI: 3.34–9.88) with an estimated AP of 0.36 (95% CI: 0.01–0.71; P = 0.04370). Conclusion: Our findings suggest that coffee consumption interacts with HLA to promote LADA.</p>}},
  author       = {{Rasouli, B. and Ahlqvist, E. and Alfredsson, L. and Andersson, T. and Carlsson, P. O. and Groop, L. and Löfvenborg, J. E. and Martinell, M. and Rosengren, A. and Tuomi, T. and Wolk, A. and Carlsson, S.}},
  issn         = {{1262-3636}},
  keywords     = {{Autoimmune diabetes; Coffee consumption; Gene–environmental interaction; LADA; Latent autoimmune diabetes in adults; Type 2 diabetes; ANDIS; diabetes; diabetics}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{354--360}},
  publisher    = {{Elsevier Masson SAS}},
  series       = {{Diabetes & Metabolism}},
  title        = {{Coffee consumption, genetic susceptibility and risk of latent autoimmune diabetes in adults : A population-based case-control study}},
  url          = {{http://dx.doi.org/10.1016/j.diabet.2018.05.002}},
  doi          = {{10.1016/j.diabet.2018.05.002}},
  volume       = {{44}},
  year         = {{2018}},
}