Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease
Pascoal, Tharick A. ; Leuzy, Antoine LU ; Therriault, Joseph ; Chamoun, Mira ; Lussier, Firoza ; Tissot, Cecile ; Strandberg, Olof LU ; Palmqvist, Sebastian LU
; Stomrud, Erik
LU
and Ferreira, Pamela C.L.
, et al.
(2023)
In Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
15(1).
- Abstract
Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in... (More)
Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.
(Less)
- author
- Pascoal, Tharick A.
; Leuzy, Antoine
LU
; Therriault, Joseph
; Chamoun, Mira
; Lussier, Firoza
; Tissot, Cecile
; Strandberg, Olof
LU
; Palmqvist, Sebastian
LU
; Stomrud, Erik
LU
and Ferreira, Pamela C.L.
, et al. (More)
- Pascoal, Tharick A.
; Leuzy, Antoine
LU
; Therriault, Joseph
; Chamoun, Mira
; Lussier, Firoza
; Tissot, Cecile
; Strandberg, Olof
LU
; Palmqvist, Sebastian
LU
; Stomrud, Erik
LU
; Ferreira, Pamela C.L.
; Ferrari-Souza, João Pedro
; Smith, Ruben
LU
; Benedet, Andrea Lessa
; Gauthier, Serge
; Hansson, Oskar
LU
and Rosa-Neto, Pedro
(Less)
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- A/T/N system, Alzheimer's disease, biomarker, diagnose, PET
- in
- Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
- volume
- 15
- issue
- 1
- article number
- e12390
- publisher
- Elsevier
- external identifiers
-
- pmid:36733847
- scopus:85152466962
- ISSN
- 2352-8729
- DOI
- 10.1002/dad2.12390
- language
- English
- LU publication?
- yes
- id
- 3c2443fc-f037-4884-b1a0-90945a11bc1f
- date added to LUP
- 2023-07-20 10:50:17
- date last changed
- 2024-04-19 23:48:40
@article{3c2443fc-f037-4884-b1a0-90945a11bc1f,
abstract = {{<p>Introduction: The optimal combination of amyloid-β/tau/neurodegeneration (A/T/N) biomarker profiles for the diagnosis of Alzheimer's disease (AD) dementia is unclear. Methods: We examined the discriminative accuracy of A/T/N combinations assessed with neuroimaging biomarkers for the differentiation of AD from cognitively unimpaired (CU) elderly and non-AD neurodegenerative diseases in the TRIAD, BioFINDER-1 and BioFINDER-2 cohorts (total n = 832) using area under the receiver operating characteristic curves (AUC). Results: For the diagnosis of AD dementia (vs. CU elderly), T biomarkers performed as well as the complete A/T/N system (AUC range: 0.90–0.99). A and T biomarkers in isolation performed as well as the complete A/T/N system in differentiating AD dementia from non-AD neurodegenerative diseases (AUC range; A biomarker: 0.84–1; T biomarker: 0.83–1). Discussion: In diagnostic settings, the use of A or T neuroimaging biomarkers alone can reduce patient burden and medical costs compared with using their combination, without significantly compromising accuracy.</p>}},
author = {{Pascoal, Tharick A. and Leuzy, Antoine and Therriault, Joseph and Chamoun, Mira and Lussier, Firoza and Tissot, Cecile and Strandberg, Olof and Palmqvist, Sebastian and Stomrud, Erik and Ferreira, Pamela C.L. and Ferrari-Souza, João Pedro and Smith, Ruben and Benedet, Andrea Lessa and Gauthier, Serge and Hansson, Oskar and Rosa-Neto, Pedro}},
issn = {{2352-8729}},
keywords = {{A/T/N system; Alzheimer's disease; biomarker; diagnose; PET}},
language = {{eng}},
number = {{1}},
publisher = {{Elsevier}},
series = {{Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring}},
title = {{Discriminative accuracy of the A/T/N scheme to identify cognitive impairment due to Alzheimer's disease}},
url = {{http://dx.doi.org/10.1002/dad2.12390}},
doi = {{10.1002/dad2.12390}},
volume = {{15}},
year = {{2023}},
}