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Past, Present, and Future of Direct Cell Reprogramming

Ahlenius, Henrik LU (2022) In Cellular Reprogramming 24(5). p.205-211
Abstract

Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell toward another identity without a pluripotent intermediate state. In addition to the opportunity for mechanistic dissection of lineage commitment in human cells, the field offer the promise of diverse applications such as for disease modeling, cell replacement therapy, regenerative medicine, and immunotherapy that have recently spurred innovation and out of the box thinking to unleash the potential of cellular plasticity.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cellular plasticity, direct conversion, direct reprogramming, induced pluripotent stem cells, regenerative medicine, transdifferentiation
in
Cellular Reprogramming
volume
24
issue
5
pages
7 pages
publisher
Mary Ann Liebert, Inc.
external identifiers
  • pmid:36219713
  • scopus:85139637615
ISSN
2152-4971
DOI
10.1089/cell.2022.0110
language
English
LU publication?
yes
id
3d93078f-75c7-478f-9e56-d2d25bf84dc4
date added to LUP
2022-12-09 14:04:07
date last changed
2024-04-04 05:42:05
@article{3d93078f-75c7-478f-9e56-d2d25bf84dc4,
  abstract     = {{<p>Budding off from the broader developmental biology and stem cell research fields, cellular reprogramming is now established as a prominent discipline in its own right. Direct cell reprogramming is defined as the cell fate conversion of a somatic cell toward another identity without a pluripotent intermediate state. In addition to the opportunity for mechanistic dissection of lineage commitment in human cells, the field offer the promise of diverse applications such as for disease modeling, cell replacement therapy, regenerative medicine, and immunotherapy that have recently spurred innovation and out of the box thinking to unleash the potential of cellular plasticity.</p>}},
  author       = {{Ahlenius, Henrik}},
  issn         = {{2152-4971}},
  keywords     = {{cellular plasticity; direct conversion; direct reprogramming; induced pluripotent stem cells; regenerative medicine; transdifferentiation}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{5}},
  pages        = {{205--211}},
  publisher    = {{Mary Ann Liebert, Inc.}},
  series       = {{Cellular Reprogramming}},
  title        = {{Past, Present, and Future of Direct Cell Reprogramming}},
  url          = {{http://dx.doi.org/10.1089/cell.2022.0110}},
  doi          = {{10.1089/cell.2022.0110}},
  volume       = {{24}},
  year         = {{2022}},
}