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The clinical significance of 10-m walk test standardizations in Parkinson’s disease

Lindholm, Beata LU ; Nilsson, Maria H. LU ; Hansson, Oskar LU and Hagell, Peter LU (2018) In Journal of Neurology 265(8). p.1829-1835
Abstract

Background: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. Aim of the study: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall prediction were also explored. Methods: 151 people with PD (mean age and PD duration, 68 and 4 years, respectively) completed the 10MWT in comfortable gait speed with static and dynamic start (two trials each), and gait speed (m/s) was recorded. Participants then registered all prospective falls for 6 months. Results: Absolute mean differences... (More)

Background: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. Aim of the study: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall prediction were also explored. Methods: 151 people with PD (mean age and PD duration, 68 and 4 years, respectively) completed the 10MWT in comfortable gait speed with static and dynamic start (two trials each), and gait speed (m/s) was recorded. Participants then registered all prospective falls for 6 months. Results: Absolute mean differences between outcomes from the various test conditions ranged between 0.016 and 0.040 m/s (effect sizes, 0.06–0.14) with high levels of agreement (intra-class correlation coefficients, 0.932–0.987) and small standard errors of measurement (0.032–0.076 m/s). Receiver operating characteristic curves showed similar discriminate abilities for prediction of future falls across conditions (areas under curves, 0.70–0.73). Cut-off points were estimated at 1.1–1.2 m/s. Conclusions: Different 10MWT standardizations yield very similar results, suggesting that there is no practical need for an acceleration distance or repeated trials when conducting this test in mild PD.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Falls, Parkinson disease, Prediction, Test standardization, The 10-m walk test
in
Journal of Neurology
volume
265
issue
8
pages
1829 - 1835
publisher
Steinkopff
external identifiers
  • scopus:85048050349
ISSN
0340-5354
DOI
10.1007/s00415-018-8921-9
language
English
LU publication?
yes
id
3dbb077f-78cd-4bee-bb29-70a0cde9336b
date added to LUP
2018-06-18 16:13:10
date last changed
2019-09-17 04:34:26
@article{3dbb077f-78cd-4bee-bb29-70a0cde9336b,
  abstract     = {<p>Background: The 10-m walk test (10MWT) is a widely used measure of gait speed in Parkinson’s disease (PD). However, it is unclear if different standardizations of its conduct impact test results. Aim of the study: We examined the clinical significance of two aspects of the standardization of the 10MWT in mild PD: static vs. dynamic start, and a single vs. repeated trials. Implications for fall prediction were also explored. Methods: 151 people with PD (mean age and PD duration, 68 and 4 years, respectively) completed the 10MWT in comfortable gait speed with static and dynamic start (two trials each), and gait speed (m/s) was recorded. Participants then registered all prospective falls for 6 months. Results: Absolute mean differences between outcomes from the various test conditions ranged between 0.016 and 0.040 m/s (effect sizes, 0.06–0.14) with high levels of agreement (intra-class correlation coefficients, 0.932–0.987) and small standard errors of measurement (0.032–0.076 m/s). Receiver operating characteristic curves showed similar discriminate abilities for prediction of future falls across conditions (areas under curves, 0.70–0.73). Cut-off points were estimated at 1.1–1.2 m/s. Conclusions: Different 10MWT standardizations yield very similar results, suggesting that there is no practical need for an acceleration distance or repeated trials when conducting this test in mild PD.</p>},
  author       = {Lindholm, Beata and Nilsson, Maria H. and Hansson, Oskar and Hagell, Peter},
  issn         = {0340-5354},
  keyword      = {Falls,Parkinson disease,Prediction,Test standardization,The 10-m walk test},
  language     = {eng},
  month        = {06},
  number       = {8},
  pages        = {1829--1835},
  publisher    = {Steinkopff},
  series       = {Journal of Neurology},
  title        = {The clinical significance of 10-m walk test standardizations in Parkinson’s disease},
  url          = {http://dx.doi.org/10.1007/s00415-018-8921-9},
  volume       = {265},
  year         = {2018},
}