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Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study

Bhoo-Pathy, Nirmala; Uiterwaal, Cuno S. P. M.; Dik, Vincent K.; Jeurnink, Suzanne M.; Bech, Bodil H.; Overvad, Kim; Halkjaer, Jytte; Tjonneland, Anne; Boutron-Ruault, Marie-Christine and Fagherazzi, Guy, et al. (2013) In Clinical Gastroenterology and Hepatology 11(11). p.1486-1492
Abstract
BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and... (More)
BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. RESULTS: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee ( HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer ( HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer ( HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. CONCLUSIONS: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer. (Less)
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keywords
Caffeinated Coffee, Decaffeinated Coffee, Tea, Pancreatic Cancer
in
Clinical Gastroenterology and Hepatology
volume
11
issue
11
pages
1486 - 1492
publisher
Elsevier
external identifiers
  • wos:000325759900023
  • scopus:84885764411
ISSN
1542-7714
DOI
10.1016/j.cgh.2013.05.029
language
English
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yes
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3eacb18d-fc54-41e2-81a8-4ab7764d78e1 (old id 4204361)
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2014-01-03 10:42:18
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2019-08-28 01:35:13
@article{3eacb18d-fc54-41e2-81a8-4ab7764d78e1,
  abstract     = {BACKGROUND & AIMS: Few modifiable risk factors have been implicated in the etiology of pancreatic cancer. There is little evidence for the effects of caffeinated coffee, decaffeinated coffee, or tea intake on risk of pancreatic cancer. We investigated the association of total coffee, caffeinated coffee, decaffeinated coffee, and tea consumption with risk of pancreatic cancer. METHODS: This study was conducted within the European Prospective Investigation into Nutrition and Cancer cohort, comprising male and female participants from 10 European countries. Between 1992 and 2000, there were 477,312 participants without cancer who completed a dietary questionnaire and were followed up to determine pancreatic cancer incidence. Coffee and tea intake was calibrated with a 24-hour dietary recall. Adjusted hazard ratios (HRs) were computed using multivariable Cox regression. RESULTS: During a mean follow-up period of 11.6 y, 865 first incidences of pancreatic cancers were reported. When divided into fourths, neither total intake of coffee (HR, 1.03; 95% confidence interval [CI], 0.83-1.27; high vs low intake), decaffeinated coffee ( HR, 1.12; 95% CI, 0.76-1.63; high vs low intake), nor tea were associated with risk of pancreatic cancer ( HR, 1.22, 95% CI, 0.95-1.56; high vs low intake). Moderately low intake of caffeinated coffee was associated with an increased risk of pancreatic cancer ( HR, 1.33; 95% CI, 1.02-1.74), compared with low intake. However, no graded dose response was observed, and the association attenuated after restriction to histologically confirmed pancreatic cancers. CONCLUSIONS: Based on an analysis of data from the European Prospective Investigation into Nutrition and Cancer cohort, total coffee, decaffeinated coffee, and tea consumption are not related to the risk of pancreatic cancer.},
  author       = {Bhoo-Pathy, Nirmala and Uiterwaal, Cuno S. P. M. and Dik, Vincent K. and Jeurnink, Suzanne M. and Bech, Bodil H. and Overvad, Kim and Halkjaer, Jytte and Tjonneland, Anne and Boutron-Ruault, Marie-Christine and Fagherazzi, Guy and Racine, Antoine and Katzke, Verena A. and Li, Kuanrong and Boeing, Heiner and Floegel, Anna and Androulidaki, Anna and Bamia, Christina and Trichopoulou, Antonia and Masala, Giovanna and Panico, Salvatore and Crosignani, Paolo and Tumino, Rosario and Vineis, Paolo and Peeters, Petra H. M. and Gavrilyuk, Oxana and Skeie, Guri and Weiderpass, Elisabete and Duell, Eric J. and Arguelles, Marcial and Molina-Montes, Esther and Navarro, Carmen and Ardanaz, Eva and Dorronsoro, Miren and Lindkvist, Bjorn and Wallström, Peter and Sund, Malin and Ye, Weimin and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy J. and Travis, Ruth C. and Duarte-Salles, Talita and Freisling, Heinz and Licaj, Idlir and Gallo, Valentina and Michaud, Dominique S. and Riboli, Elio and Bueno-De-Mesquita, H. Bas},
  issn         = {1542-7714},
  keyword      = {Caffeinated Coffee,Decaffeinated Coffee,Tea,Pancreatic Cancer},
  language     = {eng},
  number       = {11},
  pages        = {1486--1492},
  publisher    = {Elsevier},
  series       = {Clinical Gastroenterology and Hepatology},
  title        = {Intake of Coffee, Decaffeinated Coffee, or Tea Does Not Affect Risk for Pancreatic Cancer: Results From the European Prospective Investigation into Nutrition and Cancer Study},
  url          = {http://dx.doi.org/10.1016/j.cgh.2013.05.029},
  volume       = {11},
  year         = {2013},
}