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Circulating Vimentin Is Associated With Future Incidence of Stroke in a Population-Based Cohort Study

Xiao, Jun LU ; Chen, Liangwan ; Melander, Olle LU orcid ; Orho-Melander, Marju LU ; Nilsson, Jan LU ; Borné, Yan LU and Engström, Gunnar LU (2021) In Stroke: a journal of cerebral circulation 52. p.937-944
Abstract
Background and Purpose:
VIM (vimentin) is a cytoskeletal intermediate filament protein, which has been linked to atherosclerosis and thrombosis; both are important causes of stroke. We examined the relationship between circulating VIM and incidence of stroke, and if carotid plaque could modify the association in a prospective population-based cohort.

Methods:
This prospective study was based on the Malmö Diet and Cancer Cohort. A total of 4688 participants (39.7% men; mean age, 57.6 years) were examined and blood samples were collected between 1991 and 1994. Incidence of stroke was followed up to 2018. Cox’ proportional hazards regression was used to assess the relationship between VIM and... (More)
Background and Purpose:
VIM (vimentin) is a cytoskeletal intermediate filament protein, which has been linked to atherosclerosis and thrombosis; both are important causes of stroke. We examined the relationship between circulating VIM and incidence of stroke, and if carotid plaque could modify the association in a prospective population-based cohort.

Methods:
This prospective study was based on the Malmö Diet and Cancer Cohort. A total of 4688 participants (39.7% men; mean age, 57.6 years) were examined and blood samples were collected between 1991 and 1994. Incidence of stroke was followed up to 2018. Cox’ proportional hazards regression was used to assess the relationship between VIM and stroke.

Results:
During a mean follow-up of 22.0 years, a total of 528 subjects were diagnosed with stroke, among which 434 were ischemic stroke. Participants in the highest quartile (vs 1st quartile) had 1.34× higher risk of total stroke (95% CI, 1.03–1.74) and 1.47× higher of ischemic stroke (95% CI, 1.10–1.98) after adjustment for potential confounders. A significant interaction was found between carotid plaque and VIM with respect to incidence of both total stroke and ischemic stroke (P=0.041 and 0.011, respectively). After stratifying by carotid plaque, high VIM had stronger association with stroke in participants with carotid plaque, especially for the risk of ischemic stroke (adjusted hazard ratio,1.66 [95% CI, 1.23–2.25] for quartile 4 versus quartile 1 to 3).

Conclusions:
VIM is positively associated with the incidence of stroke, especially in individuals with carotid plaque. Further studies are needed to confirm the observed associations. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Stroke: a journal of cerebral circulation
volume
52
pages
8 pages
publisher
American Heart Association
external identifiers
  • scopus:85102222535
  • pmid:33535783
ISSN
1524-4628
DOI
10.1161/STROKEAHA.120.032111
language
English
LU publication?
yes
id
3ee62a94-26f0-4569-acdf-3fb02e595b8e
date added to LUP
2021-02-18 16:16:25
date last changed
2024-01-17 23:26:26
@article{3ee62a94-26f0-4569-acdf-3fb02e595b8e,
  abstract     = {{Background and Purpose:<br/>VIM (vimentin) is a cytoskeletal intermediate filament protein, which has been linked to atherosclerosis and thrombosis; both are important causes of stroke. We examined the relationship between circulating VIM and incidence of stroke, and if carotid plaque could modify the association in a prospective population-based cohort.<br/><br/>Methods:<br/>This prospective study was based on the Malmö Diet and Cancer Cohort. A total of 4688 participants (39.7% men; mean age, 57.6 years) were examined and blood samples were collected between 1991 and 1994. Incidence of stroke was followed up to 2018. Cox’ proportional hazards regression was used to assess the relationship between VIM and stroke.<br/><br/>Results:<br/>During a mean follow-up of 22.0 years, a total of 528 subjects were diagnosed with stroke, among which 434 were ischemic stroke. Participants in the highest quartile (vs 1st quartile) had 1.34× higher risk of total stroke (95% CI, 1.03–1.74) and 1.47× higher of ischemic stroke (95% CI, 1.10–1.98) after adjustment for potential confounders. A significant interaction was found between carotid plaque and VIM with respect to incidence of both total stroke and ischemic stroke (P=0.041 and 0.011, respectively). After stratifying by carotid plaque, high VIM had stronger association with stroke in participants with carotid plaque, especially for the risk of ischemic stroke (adjusted hazard ratio,1.66 [95% CI, 1.23–2.25] for quartile 4 versus quartile 1 to 3).<br/><br/>Conclusions:<br/>VIM is positively associated with the incidence of stroke, especially in individuals with carotid plaque. Further studies are needed to confirm the observed associations.}},
  author       = {{Xiao, Jun and Chen, Liangwan and Melander, Olle and Orho-Melander, Marju and Nilsson, Jan and Borné, Yan and Engström, Gunnar}},
  issn         = {{1524-4628}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{937--944}},
  publisher    = {{American Heart Association}},
  series       = {{Stroke: a journal of cerebral circulation}},
  title        = {{Circulating Vimentin Is Associated With Future Incidence of Stroke in a Population-Based Cohort Study}},
  url          = {{http://dx.doi.org/10.1161/STROKEAHA.120.032111}},
  doi          = {{10.1161/STROKEAHA.120.032111}},
  volume       = {{52}},
  year         = {{2021}},
}