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Golgi Cell Activity During Eyeblink Conditioning in Decerebrate Ferrets.

Rasmussen, Anders LU orcid ; Zucca, Riccardo ; Jirenhed, Dan-Anders LU ; Johansson, Fredrik LU ; Ortenblad, Caroline ; Svensson, Pär LU and Hesslow, Germund LU (2014) In Cerebellum 13(1). p.42-45
Abstract
Golgi cells have a central position in the cerebellar cortical network and are indirectly connected to Purkinje cells, which are important for the acquisition of learned responses in classical conditioning. In order to clarify the role of Golgi cells in classical conditioning, we made extracellular Golgi cell recordings during different stages of conditioning, using four different conditional stimuli. Our results show that forelimb and superior colliculus stimulation, but not mossy fiber stimulation, evokes a short latency increase in Golgi cell firing. These results suggest that Golgi cells are involved in modulating input to the cerebellar cortex. There were however no differences in Golgi cell activity between naïve and trained animals,... (More)
Golgi cells have a central position in the cerebellar cortical network and are indirectly connected to Purkinje cells, which are important for the acquisition of learned responses in classical conditioning. In order to clarify the role of Golgi cells in classical conditioning, we made extracellular Golgi cell recordings during different stages of conditioning, using four different conditional stimuli. Our results show that forelimb and superior colliculus stimulation, but not mossy fiber stimulation, evokes a short latency increase in Golgi cell firing. These results suggest that Golgi cells are involved in modulating input to the cerebellar cortex. There were however no differences in Golgi cell activity between naïve and trained animals, which suggests that Golgi cells are not intimately involved in the plastic changes that occur during classical conditioning. The absence of long latency effects of the conditional stimulus also questions whether Golgi cells contribute to the generation of a temporal code in the granule cells. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cerebellum
volume
13
issue
1
pages
42 - 45
publisher
Informa Healthcare
external identifiers
  • pmid:23982588
  • wos:000332156100005
  • scopus:84896494985
  • pmid:23982588
ISSN
1473-4230
DOI
10.1007/s12311-013-0518-3
project
Thinking in Time: Cognition, Communication and Learning
language
English
LU publication?
yes
id
a521ac87-864c-4ef4-af6c-c05befe68c60 (old id 4005288)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23982588?dopt=Abstract
date added to LUP
2016-04-01 10:21:40
date last changed
2022-05-16 12:08:50
@article{a521ac87-864c-4ef4-af6c-c05befe68c60,
  abstract     = {{Golgi cells have a central position in the cerebellar cortical network and are indirectly connected to Purkinje cells, which are important for the acquisition of learned responses in classical conditioning. In order to clarify the role of Golgi cells in classical conditioning, we made extracellular Golgi cell recordings during different stages of conditioning, using four different conditional stimuli. Our results show that forelimb and superior colliculus stimulation, but not mossy fiber stimulation, evokes a short latency increase in Golgi cell firing. These results suggest that Golgi cells are involved in modulating input to the cerebellar cortex. There were however no differences in Golgi cell activity between naïve and trained animals, which suggests that Golgi cells are not intimately involved in the plastic changes that occur during classical conditioning. The absence of long latency effects of the conditional stimulus also questions whether Golgi cells contribute to the generation of a temporal code in the granule cells.}},
  author       = {{Rasmussen, Anders and Zucca, Riccardo and Jirenhed, Dan-Anders and Johansson, Fredrik and Ortenblad, Caroline and Svensson, Pär and Hesslow, Germund}},
  issn         = {{1473-4230}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{42--45}},
  publisher    = {{Informa Healthcare}},
  series       = {{Cerebellum}},
  title        = {{Golgi Cell Activity During Eyeblink Conditioning in Decerebrate Ferrets.}},
  url          = {{http://dx.doi.org/10.1007/s12311-013-0518-3}},
  doi          = {{10.1007/s12311-013-0518-3}},
  volume       = {{13}},
  year         = {{2014}},
}