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Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations

Wang, Chuan; Ahlford, Annika; Jarvinen, Tiina M.; Nordmark, Gunnel; Eloranta, Maija-Leena; Gunnarsson, Iva; Svenungsson, Elisabet; Padyukov, Leonid; Sturfelt, Gunnar LU and Jönsen, Andreas LU , et al. (2013) In European Journal of Human Genetics 21(9). p.994-999
Abstract
Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and... (More)
Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities. (Less)
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publication status
published
subject
keywords
systemic lupus erythematosus, genetic-association study, Asian, Caucasian
in
European Journal of Human Genetics
volume
21
issue
9
pages
994 - 999
publisher
Nature Publishing Group
external identifiers
  • wos:000323281400016
  • scopus:84882453048
ISSN
1476-5438
DOI
10.1038/ejhg.2012.277
language
English
LU publication?
yes
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656e5109-291f-4d90-8ec7-a70aa064780c (old id 4025640)
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2013-10-01 15:24:21
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2019-08-28 01:16:40
@article{656e5109-291f-4d90-8ec7-a70aa064780c,
  abstract     = {Recent genome-wide association studies (GWASs) conducted in Asian populations have identified novel risk loci for systemic lupus erythematosus (SLE). Here, we genotyped 10 single-nucleotide polymorphisms (SNPs) in eight such loci and investigated their disease associations in three independent Caucasian SLE case-control cohorts recruited from Sweden, Finland and the United States. The disease associations of the SNPs in ETS1, IKZF1, LRRC18-WDFY4, RASGRP3, SLC15A4, TNIP1 and 16p11.2 were replicated, whereas no solid evidence of association was observed for the 7q11.23 locus in the Caucasian cohorts. SLC15A4 was significantly associated with renal involvement in SLE. The association of TNIP1 was more pronounced in SLE patients with renal and immunological disorder, which is corroborated by two previous studies in Asian cohorts. The effects of all the associated SNPs, either conferring risk for or being protective against SLE, were in the same direction in Caucasians and Asians. The magnitudes of the allelic effects for most of the SNPs were also comparable across different ethnic groups. On the contrary, remarkable differences in allele frequencies between Caucasian and Asian populations were observed for all associated SNPs. In conclusion, most of the novel SLE risk loci identified by GWASs in Asian populations were also associated with SLE in Caucasian populations. We observed both similarities and differences with respect to the effect sizes and risk allele frequencies across ethnicities.},
  author       = {Wang, Chuan and Ahlford, Annika and Jarvinen, Tiina M. and Nordmark, Gunnel and Eloranta, Maija-Leena and Gunnarsson, Iva and Svenungsson, Elisabet and Padyukov, Leonid and Sturfelt, Gunnar and Jönsen, Andreas and Bengtsson, Anders and Truedsson, Lennart and Eriksson, Catharina and Rantapaa-Dahlqvist, Solbritt and Sjowall, Christopher and Julkunen, Heikki and Criswell, Lindsey A. and Graham, Robert R. and Behrens, Timothy W. and Kere, Juha and Ronnblom, Lars and Syvanen, Ann-Christine and Sandling, Johanna K.},
  issn         = {1476-5438},
  keyword      = {systemic lupus erythematosus,genetic-association study,Asian,Caucasian},
  language     = {eng},
  number       = {9},
  pages        = {994--999},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Human Genetics},
  title        = {Genes identified in Asian SLE GWASs are also associated with SLE in Caucasian populations},
  url          = {http://dx.doi.org/10.1038/ejhg.2012.277},
  volume       = {21},
  year         = {2013},
}