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Cadmium-induced effects on bone in a population-based study of women

Akesson, A ; Bjellerup, P ; Lundh, Thomas LU ; Lidfeldt, Jonas LU ; Nerbrand, Christina LU ; Samsioe, Göran LU ; Skerfving, Staffan LU and Vahter, M (2006) In Environmental Health Perspectives 114(6). p.830-834
Abstract
High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche,... (More)
High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 mu g/L adjusted to density (0.67 mu g/g creatinine). After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary). For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022). Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
women, bone mineral density, osteoporosis, biochemical bone markers, lead, cadmium
in
Environmental Health Perspectives
volume
114
issue
6
pages
830 - 834
publisher
National Institute of Environmental Health Sciences
external identifiers
  • pmid:16759980
  • wos:000238004800029
  • scopus:33745018112
ISSN
1552-9924
DOI
10.1289/ehp.8763
language
English
LU publication?
yes
id
8ca1ac5a-893e-446f-9faa-1558cd40034a (old id 406860)
date added to LUP
2016-04-01 16:43:06
date last changed
2021-09-15 03:13:27
@article{8ca1ac5a-893e-446f-9faa-1558cd40034a,
  abstract     = {High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 mu g/L adjusted to density (0.67 mu g/g creatinine). After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p &lt; 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary). For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022). Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects.},
  author       = {Akesson, A and Bjellerup, P and Lundh, Thomas and Lidfeldt, Jonas and Nerbrand, Christina and Samsioe, Göran and Skerfving, Staffan and Vahter, M},
  issn         = {1552-9924},
  language     = {eng},
  number       = {6},
  pages        = {830--834},
  publisher    = {National Institute of Environmental Health Sciences},
  series       = {Environmental Health Perspectives},
  title        = {Cadmium-induced effects on bone in a population-based study of women},
  url          = {http://dx.doi.org/10.1289/ehp.8763},
  doi          = {10.1289/ehp.8763},
  volume       = {114},
  year         = {2006},
}