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beta-Glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations

Naumann, E ; van Rees, AB ; Önning, Gunilla LU ; Oste, R ; Wydra, M and Mensink, RP (2006) In American Journal of Clinical Nutrition 83(3). p.601-605
Abstract
Background: beta-Glucan can reduce serum concentrations of total and LDL cholesterol. The mechanism of this action is not clear, however, and it is difficult to predict the cholesterol-lowering effect of a food product enriched with beta-glucan. Objectives: We examined the effects of a beta-glucan-enriched fruit juice on serum lipids and lipoproteins and on markers of cholesterol absorption (serum concentrations of plant sterols) and synthesis (serum concentrations of lathosierol). In addition, we measured effects on lipid-soluble antioxidants. Design: After a 3-wk run-in period, healthy subjects consumed daily a fruit drink providing 5 g rice starch [placebo (control) group; n = 22] or beta-glucan from oats (n = 25) for 5 wk (parallel... (More)
Background: beta-Glucan can reduce serum concentrations of total and LDL cholesterol. The mechanism of this action is not clear, however, and it is difficult to predict the cholesterol-lowering effect of a food product enriched with beta-glucan. Objectives: We examined the effects of a beta-glucan-enriched fruit juice on serum lipids and lipoproteins and on markers of cholesterol absorption (serum concentrations of plant sterols) and synthesis (serum concentrations of lathosierol). In addition, we measured effects on lipid-soluble antioxidants. Design: After a 3-wk run-in period, healthy subjects consumed daily a fruit drink providing 5 g rice starch [placebo (control) group; n = 22] or beta-glucan from oats (n = 25) for 5 wk (parallel design). At the end of the run-in period and at the end of the intervention, blood samples were taken for analysis of lipids and lipoproteins, noncholesterol sterols, and fat-soluble antioxidants. Changes between the end of the run-in period and the end of the intervention were calculated for each subject. Differences in changes between the groups were analyzed statistically. Results: The differences between the control and beta-glucan groups in the chance in serum concentrations of total and LDL cholesterol, respectively, were -4.8% (P = 0.012) and -7.7% (P = 0.005). The differences between the groups in the change in serum concentrations of lathosterol and sitosterol were -13% (P = 0.023) and -11 % (P = 0.030), respectively. No significant effects were found on fat-soluble antioxidants. Conclusions: beta-Glucan lowers serum concentrations of total and LDL cholesterol when incorporated into a fruit drink. A reduced cholesterol absorption contributes to the cholesterol-lowering effect of beta-glucan without affecting plasma concentrations of lipid-soluble antioxidants. (Less)
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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
beta-glucan, lathosterol, sitosterol, campesterol, healthy subjects, antioxidants, cholesterol
in
American Journal of Clinical Nutrition
volume
83
issue
3
pages
601 - 605
publisher
Oxford University Press
external identifiers
  • pmid:16522906
  • wos:000236073100011
  • scopus:33645634224
ISSN
1938-3207
language
English
LU publication?
yes
id
c9e770d5-0ced-40d8-b9dc-d509be5444d1 (old id 415867)
alternative location
http://www.ajcn.org/cgi/content/abstract/83/3/601
date added to LUP
2016-04-01 17:02:11
date last changed
2020-11-03 04:34:41
@article{c9e770d5-0ced-40d8-b9dc-d509be5444d1,
  abstract     = {Background: beta-Glucan can reduce serum concentrations of total and LDL cholesterol. The mechanism of this action is not clear, however, and it is difficult to predict the cholesterol-lowering effect of a food product enriched with beta-glucan. Objectives: We examined the effects of a beta-glucan-enriched fruit juice on serum lipids and lipoproteins and on markers of cholesterol absorption (serum concentrations of plant sterols) and synthesis (serum concentrations of lathosierol). In addition, we measured effects on lipid-soluble antioxidants. Design: After a 3-wk run-in period, healthy subjects consumed daily a fruit drink providing 5 g rice starch [placebo (control) group; n = 22] or beta-glucan from oats (n = 25) for 5 wk (parallel design). At the end of the run-in period and at the end of the intervention, blood samples were taken for analysis of lipids and lipoproteins, noncholesterol sterols, and fat-soluble antioxidants. Changes between the end of the run-in period and the end of the intervention were calculated for each subject. Differences in changes between the groups were analyzed statistically. Results: The differences between the control and beta-glucan groups in the chance in serum concentrations of total and LDL cholesterol, respectively, were -4.8% (P = 0.012) and -7.7% (P = 0.005). The differences between the groups in the change in serum concentrations of lathosterol and sitosterol were -13% (P = 0.023) and -11 % (P = 0.030), respectively. No significant effects were found on fat-soluble antioxidants. Conclusions: beta-Glucan lowers serum concentrations of total and LDL cholesterol when incorporated into a fruit drink. A reduced cholesterol absorption contributes to the cholesterol-lowering effect of beta-glucan without affecting plasma concentrations of lipid-soluble antioxidants.},
  author       = {Naumann, E and van Rees, AB and Önning, Gunilla and Oste, R and Wydra, M and Mensink, RP},
  issn         = {1938-3207},
  language     = {eng},
  number       = {3},
  pages        = {601--605},
  publisher    = {Oxford University Press},
  series       = {American Journal of Clinical Nutrition},
  title        = {beta-Glucan incorporated into a fruit drink effectively lowers serum LDL-cholesterol concentrations},
  url          = {http://www.ajcn.org/cgi/content/abstract/83/3/601},
  volume       = {83},
  year         = {2006},
}