The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus
(2006) In Journal of Antibiotics 59(1). p.53-56- Abstract
- In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/417817
- author
- Mierau, V ; de la Parra, Veronica LU ; Sterner, Olov LU and Anke, T
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- activities, cytotoxic, Dasyscyphus niveus, niveulone, dasyscyphins, A similar to C
- in
- Journal of Antibiotics
- volume
- 59
- issue
- 1
- pages
- 53 - 56
- publisher
- Japan Antibiotics Research Association
- external identifiers
-
- pmid:16568719
- wos:000235298300008
- scopus:33644555234
- ISSN
- 0021-8820
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 0cc4822f-2c4a-4056-996c-4e1b5085d51d (old id 417817)
- alternative location
- http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article
- date added to LUP
- 2016-04-01 15:33:38
- date last changed
- 2022-01-28 05:54:37
@article{0cc4822f-2c4a-4056-996c-4e1b5085d51d, abstract = {{In the course of a screening for cytotoxic Compounds from fungi four new terpenoid metabolites, named dasyscyphins A, B, C, and niveulone were isolated from fermentations of Dasyscyphus niveus strain A0101. While dasyscyphin A (1) exhibited no significant biological activities in our test systems dasyscyphin B (2) and dasyscyphin C (3) showed cytotoxic activities against human (HepG2, Hela S3, U937, Colo-320, Jurkat) cell lines with IC50-values of 0.5 similar to 3 mu g/ml while the activity of niveulone (4) was less pronounced. Only modest or weak antibiotic properties were observed for (2) and (3).}}, author = {{Mierau, V and de la Parra, Veronica and Sterner, Olov and Anke, T}}, issn = {{0021-8820}}, keywords = {{activities; cytotoxic; Dasyscyphus niveus; niveulone; dasyscyphins; A similar to C}}, language = {{eng}}, number = {{1}}, pages = {{53--56}}, publisher = {{Japan Antibiotics Research Association}}, series = {{Journal of Antibiotics}}, title = {{The dasyscyphins A similar to C and niveulone, new biologically active compounds from the ascomycete Dasyscyphus niveus}}, url = {{http://www.jstage.jst.go.jp/article/antibiotics/59/1/59_53/_article}}, volume = {{59}}, year = {{2006}}, }