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Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.

Singh, Kalpana LU ; Nordström, Therése LU ; Mörgelin, Matthias LU ; Brant, Marta LU ; Cardell, Lars-Olaf LU and Riesbeck, Kristian LU (2014) In Journal of Infectious Diseases 209(9). p.1418-1428
Abstract
Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in... (More)
Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Journal of Infectious Diseases
volume
209
issue
9
pages
1418 - 1428
publisher
Oxford University Press
external identifiers
  • pmid:24218509
  • wos:000334689700014
  • scopus:84898891984
ISSN
1537-6613
DOI
10.1093/infdis/jit593
language
English
LU publication?
yes
id
39c88de8-47ef-4fbd-8881-075f4cc35a5a (old id 4179561)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24218509?dopt=Abstract
date added to LUP
2013-12-04 14:04:07
date last changed
2017-11-05 03:04:09
@article{39c88de8-47ef-4fbd-8881-075f4cc35a5a,
  abstract     = {Haemophilus influenzae (Hi) causes respiratory tract infections and is also considered as a commensal, particularly in pre-school children. Tonsils from patients (n=617) undergoing tonsillectomy due to chronical infection or hypertrophy were examined. We found that 51 % of tonsils were positive for Hi, and in 95 % of cases analysed in detail (n=39) Hi resided intracellularly in the core tonsillar tissue. Patients harboured several intracellular unique strains and the majority were non-typeable Hi (NTHi). Interestingly, the isolated NTHi bound soluble immunoglobulin (Ig) D at the constant heavy chain domain 1 as revealed by recombinant IgD/IgG chimeras. NTHi also interacted with B lymphocytes via the IgD B cell receptor resulting in internalization of bacteria, T-cell independent activation via Toll like receptor 9, and differentiation into non-NTHi specific IgM producing cells. Taken together, IgD-binding NTHi leads to an unspecific immune response and may support the bacteria to circumvent the host defense.},
  author       = {Singh, Kalpana and Nordström, Therése and Mörgelin, Matthias and Brant, Marta and Cardell, Lars-Olaf and Riesbeck, Kristian},
  issn         = {1537-6613},
  language     = {eng},
  number       = {9},
  pages        = {1418--1428},
  publisher    = {Oxford University Press},
  series       = {Journal of Infectious Diseases},
  title        = {Haemophilus influenzae reside in tonsills and use IgD binding as an evasion strategy.},
  url          = {http://dx.doi.org/10.1093/infdis/jit593},
  volume       = {209},
  year         = {2014},
}