A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects
Fredriksson, Jenny LU ; Nilsson, Emma A LU
; Orho-Melander, Marju
LU
; Groop, Leif
LU
and Ridderstråle, Martin
LU
(2006)
In International Journal of Obesity
30(2).
p.226-232
- Abstract
- Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was... (More)
- Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele (G/T and T/T) than among carriers of the G/G genotype (0.91 +/- 0.06 for G/T and T/T carriers vs 0.66 +/- 0.09 for G/G carriers, P=0.013). Carriers of the T allele also had significantly higher body fat percent compared to G/G carriers (65 +/- 6 vs 56 +/- 10%, P=0.011). Conclusion: Our results indicate that genetic variation in APM1 influences the expression of the gene in visceral adipose tissue and suggest a potential role for such variation in regulation of body fat accumulation in obese subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/418155
- author
- Fredriksson, Jenny
LU
; Nilsson, Emma A
LU
; Orho-Melander, Marju
LU
; Groop, Leif
LU
and Ridderstråle, Martin
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- adiponectin, APM1, gene expression, adipose tissue
- in
- International Journal of Obesity
- volume
- 30
- issue
- 2
- pages
- 226 - 232
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000235133600004
- pmid:16231017
- scopus:32544460094
- ISSN
- 1476-5497
- DOI
- 10.1038/sj.ijo.0803138
- language
- English
- LU publication?
- yes
- id
- ea545ddf-d6d3-4072-9687-5d98f9159835 (old id 418155)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16231017&dopt=Abstract
- date added to LUP
- 2016-04-01 12:30:08
- date last changed
- 2024-04-09 15:53:35
@article{ea545ddf-d6d3-4072-9687-5d98f9159835,
abstract = {{Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele (G/T and T/T) than among carriers of the G/G genotype (0.91 +/- 0.06 for G/T and T/T carriers vs 0.66 +/- 0.09 for G/G carriers, P=0.013). Carriers of the T allele also had significantly higher body fat percent compared to G/G carriers (65 +/- 6 vs 56 +/- 10%, P=0.011). Conclusion: Our results indicate that genetic variation in APM1 influences the expression of the gene in visceral adipose tissue and suggest a potential role for such variation in regulation of body fat accumulation in obese subjects.}},
author = {{Fredriksson, Jenny and Nilsson, Emma A and Orho-Melander, Marju and Groop, Leif and Ridderstråle, Martin}},
issn = {{1476-5497}},
keywords = {{adiponectin; APM1; gene expression; adipose tissue}},
language = {{eng}},
number = {{2}},
pages = {{226--232}},
publisher = {{Nature Publishing Group}},
series = {{International Journal of Obesity}},
title = {{A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects}},
url = {{http://dx.doi.org/10.1038/sj.ijo.0803138}},
doi = {{10.1038/sj.ijo.0803138}},
volume = {{30}},
year = {{2006}},
}