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A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects

Fredriksson, Jenny LU ; Nilsson, Emma A LU ; Orho-Melander, Marju LU ; Groop, Leif LU and Ridderstråle, Martin LU (2006) In International Journal of Obesity 30(2). p.226-232
Abstract
Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was... (More)
Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele (G/T and T/T) than among carriers of the G/G genotype (0.91 +/- 0.06 for G/T and T/T carriers vs 0.66 +/- 0.09 for G/G carriers, P=0.013). Carriers of the T allele also had significantly higher body fat percent compared to G/G carriers (65 +/- 6 vs 56 +/- 10%, P=0.011). Conclusion: Our results indicate that genetic variation in APM1 influences the expression of the gene in visceral adipose tissue and suggest a potential role for such variation in regulation of body fat accumulation in obese subjects. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
adiponectin, APM1, gene expression, adipose tissue
in
International Journal of Obesity
volume
30
issue
2
pages
226 - 232
publisher
Nature Publishing Group
external identifiers
  • wos:000235133600004
  • pmid:16231017
  • scopus:32544460094
ISSN
1476-5497
DOI
10.1038/sj.ijo.0803138
language
English
LU publication?
yes
id
ea545ddf-d6d3-4072-9687-5d98f9159835 (old id 418155)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16231017&dopt=Abstract
date added to LUP
2016-04-01 12:30:08
date last changed
2021-10-06 05:14:04
@article{ea545ddf-d6d3-4072-9687-5d98f9159835,
  abstract     = {Objective: Reduced serum adiponectin levels have been found in obesity and type 2 diabetes and variations in the adiponectin gene (APM1) have been associated with type 2 diabetes and features of the metabolic syndrome in different populations. Study Design: Here, we investigated the expression of APM1 in adipose tissue and studied the relationship between variation in APM1 expression, the APM1 G276T polymorphism, the common PPARG Pro12Ala polymorphism and clinical features of 36 morbidly obese (body mass index (BMI) 41.5 +/- 4.9 kg/m(2)) nondiabetic subjects. Results: APM1 mRNA expression in visceral fat was correlated with serum adiponectin levels (r=0.54, P=0.012). In visceral, but not in subcutaneous, adipose tissue APM1 mRNA level was 38% higher among carriers of the APM1 G276T T allele (G/T and T/T) than among carriers of the G/G genotype (0.91 +/- 0.06 for G/T and T/T carriers vs 0.66 +/- 0.09 for G/G carriers, P=0.013). Carriers of the T allele also had significantly higher body fat percent compared to G/G carriers (65 +/- 6 vs 56 +/- 10%, P=0.011). Conclusion: Our results indicate that genetic variation in APM1 influences the expression of the gene in visceral adipose tissue and suggest a potential role for such variation in regulation of body fat accumulation in obese subjects.},
  author       = {Fredriksson, Jenny and Nilsson, Emma A and Orho-Melander, Marju and Groop, Leif and Ridderstråle, Martin},
  issn         = {1476-5497},
  language     = {eng},
  number       = {2},
  pages        = {226--232},
  publisher    = {Nature Publishing Group},
  series       = {International Journal of Obesity},
  title        = {A polymorphism in the adiponectin gene influences adiponectin expression levels in visceral fat in obese subjects},
  url          = {http://dx.doi.org/10.1038/sj.ijo.0803138},
  doi          = {10.1038/sj.ijo.0803138},
  volume       = {30},
  year         = {2006},
}