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Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma

Fernebro, Josefin LU ; Francis, Princy LU ; Edén, Patrik LU ; Borg, Åke LU ; Panagopoulos, Ioannis LU ; Mertens, Fredrik LU ; Vallon-Christersson, Johan LU orcid ; Åkerman, Måns LU ; Rydholm, Anders LU and Bauer, H , et al. (2006) In International Journal of Cancer 118(5). p.1165-1172
Abstract
We applied 27k spotted cDNA microarray slides to assess gene expression profiles in 26 samples from 24 patients with synovial sarcomas (SS). The data were analyzed in relation to histopathologic type, cytogenetic aberrations, gene fusion type and development of distant metastases. Supervised analysis based on gene fusion type in 12 SS with SS18/SSXI and 9 with SS18/SSX2 revealed significant differences in gene expression profiles. Among the discriminators were several genes that have previously been found to be upregulated in SS, including AXL, ZIC2, SPAG7, AGRN, FOXC1, NCAM1 and multiple metallothioneins. Histopathology and degree of cytogenetic complexity did not significantly influence expression, whereas a genetic signature that... (More)
We applied 27k spotted cDNA microarray slides to assess gene expression profiles in 26 samples from 24 patients with synovial sarcomas (SS). The data were analyzed in relation to histopathologic type, cytogenetic aberrations, gene fusion type and development of distant metastases. Supervised analysis based on gene fusion type in 12 SS with SS18/SSXI and 9 with SS18/SSX2 revealed significant differences in gene expression profiles. Among the discriminators were several genes that have previously been found to be upregulated in SS, including AXL, ZIC2, SPAG7, AGRN, FOXC1, NCAM1 and multiple metallothioneins. Histopathology and degree of cytogenetic complexity did not significantly influence expression, whereas a genetic signature that related to development of metastases could be discerned, albeit with a high false-positive rate. In conclusion, our findings demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects. (c) 2005 Wiley-Liss, Inc. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gene expression, synovial sarcoma, cDNA microarray, SS18/SSX
in
International Journal of Cancer
volume
118
issue
5
pages
1165 - 1172
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000235056100012
  • pmid:16152617
  • scopus:31844450589
ISSN
0020-7136
DOI
10.1002/ijc.21475
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Genetics (013022003), Department of Orthopaedics (Lund) (013028000), Pathology, (Lund) (013030000), Computational biology and biological physics (000006113), Oncology, MV (013035000)
id
e508a05c-ddb5-4ca1-b109-7bf2789b150d (old id 418171)
date added to LUP
2016-04-01 11:34:06
date last changed
2024-01-07 12:43:41
@article{e508a05c-ddb5-4ca1-b109-7bf2789b150d,
  abstract     = {{We applied 27k spotted cDNA microarray slides to assess gene expression profiles in 26 samples from 24 patients with synovial sarcomas (SS). The data were analyzed in relation to histopathologic type, cytogenetic aberrations, gene fusion type and development of distant metastases. Supervised analysis based on gene fusion type in 12 SS with SS18/SSXI and 9 with SS18/SSX2 revealed significant differences in gene expression profiles. Among the discriminators were several genes that have previously been found to be upregulated in SS, including AXL, ZIC2, SPAG7, AGRN, FOXC1, NCAM1 and multiple metallothioneins. Histopathology and degree of cytogenetic complexity did not significantly influence expression, whereas a genetic signature that related to development of metastases could be discerned, albeit with a high false-positive rate. In conclusion, our findings demonstrate differentially expressed genes for the 2 major gene fusion variants in SS, SS18/SSX1 and SS18/SSX2, and thereby suggest that these result in different downstream effects. (c) 2005 Wiley-Liss, Inc.}},
  author       = {{Fernebro, Josefin and Francis, Princy and Edén, Patrik and Borg, Åke and Panagopoulos, Ioannis and Mertens, Fredrik and Vallon-Christersson, Johan and Åkerman, Måns and Rydholm, Anders and Bauer, H and Mandahl, Nils and Nilbert, Mef}},
  issn         = {{0020-7136}},
  keywords     = {{gene expression; synovial sarcoma; cDNA microarray; SS18/SSX}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1165--1172}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{International Journal of Cancer}},
  title        = {{Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma}},
  url          = {{http://dx.doi.org/10.1002/ijc.21475}},
  doi          = {{10.1002/ijc.21475}},
  volume       = {{118}},
  year         = {{2006}},
}