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The association between sociodemographic characteristics and dementia in patients with atrial fibrillation

Wändell, Per LU ; Carlsson, Axel C. ; Li, Xinjun LU ; Gasevic, Danijela ; Sundquist, Jan LU and Sundquist, Kristina LU (2020) In Aging clinical and experimental research 32(11). p.2319-2327
Abstract

Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational... (More)

Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational levels (reference: highest level) were associated with increased dementia, HRs (95% CI) for basic school for men 1.23 (1.18–1.29) and women 1.36 (1.30–1.42), and middle-level school for men 1.17 (1.11–1.22) and women 1.28 (1.22–1.34). Divorced men and women (reference: married) showed increased risk of dementia, HR 1.07 (1.01–1.13) and 1.12 (1.06–1.18), respectively, while widowed men showed lower risk, HR 0.84 (0.80–0.88). High deprivation neighborhood socio-economic status (NSES; reference: medium level) was associated with increased dementia in men, HR 1.11 (1.05–1.17), and low deprivation neighborhood socio-economic status (NSES) with increased dementia in men and women, HR 1.12 (1.06–1.18) and 1.18 (1.12–1.24), respectively. Conclusions: Some results were expected, i.e. association between lower educational level and dementia. The higher risk of dementia in low deprivation NSES-areas could be due to a higher awareness about dementia, and subsequent earlier diagnosis and treatment of dementia.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Atrial fibrillation, Dementia, Gender, Marital status, Socio-economic factors
in
Aging clinical and experimental research
volume
32
issue
11
pages
9 pages
publisher
Kurtis
external identifiers
  • pmid:31927710
  • scopus:85077906678
ISSN
1594-0667
DOI
10.1007/s40520-019-01449-3
language
English
LU publication?
yes
id
418778c9-d954-4624-917f-403163aa016d
date added to LUP
2021-01-04 12:00:21
date last changed
2021-06-23 04:16:32
@article{418778c9-d954-4624-917f-403163aa016d,
  abstract     = {<p>Objectives: Association between socio-demographic factors and dementia risk is studied in general but not for atrial fibrillation (AF) patients. Methods: We studied AF patients ≥ 45 years in Sweden 1998–2012 (n = 537,513) using the Total Population Register for socio-demographic factors, the Swedish Cause of Death Register, and the National Patient Register (NPR) for incident dementia. Cox regression with hazard ratios (HR) and 95% confidence intervals (CI) was used for the association between exposure and outcome, adjusting for age and comorbidities. Results: Totally 30,332 patients (5.6%) were diagnosed with dementia during the follow-up (mean 5.4 years). Of these, 14,097 were men (4.9%) and 16,235 were women (6.5%). Lower educational levels (reference: highest level) were associated with increased dementia, HRs (95% CI) for basic school for men 1.23 (1.18–1.29) and women 1.36 (1.30–1.42), and middle-level school for men 1.17 (1.11–1.22) and women 1.28 (1.22–1.34). Divorced men and women (reference: married) showed increased risk of dementia, HR 1.07 (1.01–1.13) and 1.12 (1.06–1.18), respectively, while widowed men showed lower risk, HR 0.84 (0.80–0.88). High deprivation neighborhood socio-economic status (NSES; reference: medium level) was associated with increased dementia in men, HR 1.11 (1.05–1.17), and low deprivation neighborhood socio-economic status (NSES) with increased dementia in men and women, HR 1.12 (1.06–1.18) and 1.18 (1.12–1.24), respectively. Conclusions: Some results were expected, i.e. association between lower educational level and dementia. The higher risk of dementia in low deprivation NSES-areas could be due to a higher awareness about dementia, and subsequent earlier diagnosis and treatment of dementia.</p>},
  author       = {Wändell, Per and Carlsson, Axel C. and Li, Xinjun and Gasevic, Danijela and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1594-0667},
  language     = {eng},
  number       = {11},
  pages        = {2319--2327},
  publisher    = {Kurtis},
  series       = {Aging clinical and experimental research},
  title        = {The association between sociodemographic characteristics and dementia in patients with atrial fibrillation},
  url          = {http://dx.doi.org/10.1007/s40520-019-01449-3},
  doi          = {10.1007/s40520-019-01449-3},
  volume       = {32},
  year         = {2020},
}