Advanced

Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals

Karlsson, Ingrid LU ; Tingstedt, Jeanette Linnea; Sahin, Gülsen Özkaya LU ; Hansen, Mikkel; Szojka, Zsofia LU ; Buggert, Marcus; Biague, Antonio; Da Silva, Zacharias; Månsson, Fredrik LU and Esbjörnsson, Joakim LU , et al. (2019) In The Journal of infectious diseases 219(11). p.1749-1754
Abstract

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that... (More)

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.

(Less)
Please use this url to cite or link to this publication:
@article{4195ea3c-a4b8-4b6d-b5a4-da0d7286eafe,
  abstract     = {<p>Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.</p>},
  author       = {Karlsson, Ingrid and Tingstedt, Jeanette Linnea and Sahin, Gülsen Özkaya and Hansen, Mikkel and Szojka, Zsofia and Buggert, Marcus and Biague, Antonio and Da Silva, Zacharias and Månsson, Fredrik and Esbjörnsson, Joakim and Norrgren, Hans and Medstrand, Patrik and Fomsgaard, Anders and Jansson, Marianne and , },
  issn         = {1537-6613},
  language     = {eng},
  month        = {02},
  number       = {11},
  pages        = {1749--1754},
  publisher    = {Oxford University Press},
  series       = {The Journal of infectious diseases},
  title        = {Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals},
  url          = {http://dx.doi.org/10.1093/infdis/jiz001},
  volume       = {219},
  year         = {2019},
}