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Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals

Karlsson, Ingrid LU ; Tingstedt, Jeanette Linnea ; Sahin, Gülsen Özkaya LU ; Hansen, Mikkel ; Szojka, Zsofia LU ; Buggert, Marcus ; Biague, Antonio ; Da Silva, Zacharias ; Månsson, Fredrik LU and Esbjörnsson, Joakim LU , et al. (2019) In The Journal of infectious diseases 219(11). p.1749-1754
Abstract

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that... (More)

Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.

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type
Contribution to journal
publication status
published
subject
in
The Journal of infectious diseases
volume
219
issue
11
pages
1749 - 1754
publisher
Oxford University Press
external identifiers
  • pmid:30715363
  • scopus:85065641534
ISSN
1537-6613
DOI
10.1093/infdis/jiz001
language
English
LU publication?
yes
id
4195ea3c-a4b8-4b6d-b5a4-da0d7286eafe
date added to LUP
2019-03-27 14:25:51
date last changed
2021-09-15 05:59:08
@article{4195ea3c-a4b8-4b6d-b5a4-da0d7286eafe,
  abstract     = {<p>Disease progression of human immunodeficiency virus type 1 (HIV-1) is delayed by HIV type 2 (HIV-2) in individuals with dual HIV-1/HIV-2 infection. The protective mechanisms, however, are still to be revealed. In the current study we examined type-specific and cross-reactive antibody-dependent cellular cytotoxicity (ADCC) in HIV-1 and HIV-2 monoinfection or dual infection. Of note, intertype cross-reactive antibodies that mediated HIV-1 envelope glycoprotein (Env)-targeted ADCC were frequently identified in HIV-2-infected individuals. Furthermore, the magnitude of HIV-1 cross-reactive ADCC activity during HIV-2 infections depended on the HIV-1 Env origin and was associated with the duration of infection. These results suggest that preexisting antibodies against HIV-2, which mediate intertype ADCC, might contribute to control of HIV-1 during dual infection.</p>},
  author       = {Karlsson, Ingrid and Tingstedt, Jeanette Linnea and Sahin, Gülsen Özkaya and Hansen, Mikkel and Szojka, Zsofia and Buggert, Marcus and Biague, Antonio and Da Silva, Zacharias and Månsson, Fredrik and Esbjörnsson, Joakim and Norrgren, Hans and Medstrand, Patrik and Fomsgaard, Anders and Jansson, Marianne},
  issn         = {1537-6613},
  language     = {eng},
  month        = {02},
  number       = {11},
  pages        = {1749--1754},
  publisher    = {Oxford University Press},
  series       = {The Journal of infectious diseases},
  title        = {Cross-Reactive Antibodies With the Capacity to Mediate HIV-1 Envelope Glycoprotein-Targeted Antibody-Dependent Cellular Cytotoxicity Identified in HIV-2-Infected Individuals},
  url          = {http://dx.doi.org/10.1093/infdis/jiz001},
  doi          = {10.1093/infdis/jiz001},
  volume       = {219},
  year         = {2019},
}