A Case of Alport Syndrome with Posttransplant Antiglomerular Basement Membrane Disease despite Negative Antiglomerular Basement Membrane Antibodies by EIA Treated with Plasmapheresis and Intravenous Immunoglobulin.
Armstead, Sumiko I ; Hellmark, Thomas LU
; Wieslander, Jörgen
LU
; Zhou, Xin J
; Saxena, Ramesh
and Rajora, Nilum
(2013)
In Case reports in transplantation
2013(Dec 2).
- Abstract
- Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here we present a case of a 22-year-old male with end-stage renal disease secondary to Alport syndrome, with a previously failed renal allograft, who received a second deceased-donor kidney transplant. Six days after transplantation, he developed acute kidney injury. The serum anti-GBM IgG was negative by enzyme immunoassay (EIA). On biopsy, he had crescentic glomerulonephritis with linear GBM fixation of IgG. With further analysis by western blotting, we were able to detect antibodies to an... (More)
- Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here we present a case of a 22-year-old male with end-stage renal disease secondary to Alport syndrome, with a previously failed renal allograft, who received a second deceased-donor kidney transplant. Six days after transplantation, he developed acute kidney injury. The serum anti-GBM IgG was negative by enzyme immunoassay (EIA). On biopsy, he had crescentic glomerulonephritis with linear GBM fixation of IgG. With further analysis by western blotting, we were able to detect antibodies to an unidentified protein from the basement membrane. This patient was treated with plasmapheresis twice per week and monthly intravenous immunoglobulin (IVIG) for a total of five months. At the end of treatment, these unknown antibodies were no longer detected. His renal function improved, and he has not required dialysis. We conclude that anti-GBM disease in patients with Alport Syndrome may be caused by circulating antibodies to other components of the basement membrane that are undetectable by routine anti-GBM EIA and may respond to treatment with plasmapheresis and IVIG. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4223125
- author
- Armstead, Sumiko I
; Hellmark, Thomas
LU
; Wieslander, Jörgen
LU
; Zhou, Xin J
; Saxena, Ramesh
and Rajora, Nilum
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Case reports in transplantation
- volume
- 2013
- issue
- Dec 2
- article number
- 164016
- publisher
- Hindawi Limited
- external identifiers
-
- pmid:24363950
- pmid:24363950
- ISSN
- 2090-6943
- DOI
- 10.1155/2013/164016
- language
- English
- LU publication?
- yes
- id
- ad82c714-072f-4dd4-b91e-7d5d978e180a (old id 4223125)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/24363950?dopt=Abstract
- date added to LUP
- 2016-04-01 13:50:58
- date last changed
- 2019-03-08 02:47:54
@article{ad82c714-072f-4dd4-b91e-7d5d978e180a,
abstract = {{Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here we present a case of a 22-year-old male with end-stage renal disease secondary to Alport syndrome, with a previously failed renal allograft, who received a second deceased-donor kidney transplant. Six days after transplantation, he developed acute kidney injury. The serum anti-GBM IgG was negative by enzyme immunoassay (EIA). On biopsy, he had crescentic glomerulonephritis with linear GBM fixation of IgG. With further analysis by western blotting, we were able to detect antibodies to an unidentified protein from the basement membrane. This patient was treated with plasmapheresis twice per week and monthly intravenous immunoglobulin (IVIG) for a total of five months. At the end of treatment, these unknown antibodies were no longer detected. His renal function improved, and he has not required dialysis. We conclude that anti-GBM disease in patients with Alport Syndrome may be caused by circulating antibodies to other components of the basement membrane that are undetectable by routine anti-GBM EIA and may respond to treatment with plasmapheresis and IVIG.}},
author = {{Armstead, Sumiko I and Hellmark, Thomas and Wieslander, Jörgen and Zhou, Xin J and Saxena, Ramesh and Rajora, Nilum}},
issn = {{2090-6943}},
language = {{eng}},
number = {{Dec 2}},
publisher = {{Hindawi Limited}},
series = {{Case reports in transplantation}},
title = {{A Case of Alport Syndrome with Posttransplant Antiglomerular Basement Membrane Disease despite Negative Antiglomerular Basement Membrane Antibodies by EIA Treated with Plasmapheresis and Intravenous Immunoglobulin.}},
url = {{https://lup.lub.lu.se/search/files/3624270/4437966}},
doi = {{10.1155/2013/164016}},
volume = {{2013}},
year = {{2013}},
}