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Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.

Macchia, Gemma; Hansén Nord, Karolin LU ; D'Alessandro, Giuseppina; Nilsson, Jenny LU ; Magnusson, Linda LU ; Mandahl, Nils LU ; Storlazzi, Clelia Tiziana and Mertens, Fredrik LU (2014) In Oncology Reports 31(2). p.807-811
Abstract
Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped by fluorescence in situ hybridization (FISH) and single nucleotide polymorphism array analyses, and the status of the HMGA2 gene was evaluated by FISH and/or quantitative PCR. We found an overlapping deletion on 15q in two cases, but no recurring breakpoint among the other cases. In addition, all cases displayed rearrangement of HMGA2 at the... (More)
Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped by fluorescence in situ hybridization (FISH) and single nucleotide polymorphism array analyses, and the status of the HMGA2 gene was evaluated by FISH and/or quantitative PCR. We found an overlapping deletion on 15q in two cases, but no recurring breakpoint among the other cases. In addition, all cases displayed rearrangement of HMGA2 at the genomic or the transcriptional level. Although 15q rearrangements sometimes are noted as the sole aberration at cytogenetic analysis of conventional lipomas, they are secondary to HMGA2 deregulation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Oncology Reports
volume
31
issue
2
pages
807 - 811
publisher
D.A. Spandidos
external identifiers
  • pmid:24297246
  • wos:000332694400038
  • scopus:84892378869
ISSN
1791-2431
DOI
10.3892/or.2013.2889
language
English
LU publication?
yes
id
2be040b5-be81-41d4-a711-5e4f7fc7f99c (old id 4225313)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24297246?dopt=Abstract
date added to LUP
2014-01-02 22:47:03
date last changed
2017-01-01 03:52:06
@article{2be040b5-be81-41d4-a711-5e4f7fc7f99c,
  abstract     = {Rearrangements of chromosome arm 15q are rare but recurrent in conventional lipomas, a tumor type often showing deregulated expression of the HMGA2 gene. In order to assess whether 15q rearrangements could constitute a distinct pathogenetic mechanism, we studied seven cases of conventional lipoma that at G-banding analysis had various rearrangements of 15q12-q21. The breakpoints in 15q were mapped by fluorescence in situ hybridization (FISH) and single nucleotide polymorphism array analyses, and the status of the HMGA2 gene was evaluated by FISH and/or quantitative PCR. We found an overlapping deletion on 15q in two cases, but no recurring breakpoint among the other cases. In addition, all cases displayed rearrangement of HMGA2 at the genomic or the transcriptional level. Although 15q rearrangements sometimes are noted as the sole aberration at cytogenetic analysis of conventional lipomas, they are secondary to HMGA2 deregulation.},
  author       = {Macchia, Gemma and Hansén Nord, Karolin and D'Alessandro, Giuseppina and Nilsson, Jenny and Magnusson, Linda and Mandahl, Nils and Storlazzi, Clelia Tiziana and Mertens, Fredrik},
  issn         = {1791-2431},
  language     = {eng},
  number       = {2},
  pages        = {807--811},
  publisher    = {D.A. Spandidos},
  series       = {Oncology Reports},
  title        = {Rearrangements of chromosome bands 15q12-q21 are secondary to HMGA2 deregulation in conventional lipoma.},
  url          = {http://dx.doi.org/10.3892/or.2013.2889},
  volume       = {31},
  year         = {2014},
}