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Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity

Kabir, Nuzhat N. and Kazi, Julhash U. LU (2011) In Genetics and Molecular Biology 34(4). p.587-591
Abstract
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases... (More)
Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties. (Less)
Please use this url to cite or link to this publication:
author
publishing date
type
Contribution to journal
publication status
published
subject
keywords
aPK, bovine, ePK, kinome
in
Genetics and Molecular Biology
volume
34
issue
4
pages
587 - 591
publisher
Sociedade Brasileira de Genética
external identifiers
  • scopus:82355164475
ISSN
1678-4685
DOI
10.1590/S1415-47572011005000035
language
English
LU publication?
no
id
0f4b37d2-a309-4c4d-903c-2e73f5e1223a (old id 4250273)
alternative location
https://www.researchgate.net/publication/51981555_Comparative_analysis_of_human_and_bovine_protein_kinases_reveals_unique_relationship_and_functional_diversity/file/d912f511d2257b7f69.pdf?origin=publication_detail
date added to LUP
2014-02-13 17:13:11
date last changed
2017-02-26 04:33:59
@article{0f4b37d2-a309-4c4d-903c-2e73f5e1223a,
  abstract     = {Reversible protein phosphorylation by protein kinases and phosphatases is a common event in various cellular processes. The eukaryotic protein kinase superfamily, which is one of the largest superfamilies of eukaryotic proteins, plays several roles in cell signaling and diseases. We identified 482 eukaryotic protein kinases and 39 atypical protein kinases in the bovine genome, by searching publicly accessible genetic-sequence databases. Bovines have 512 putative protein kinases, each orthologous to a human kinase. Whereas orthologous kinase pairs are, on an average, 90.6% identical, orthologous kinase catalytic domain pairs are, on an average, 95.9% identical at the amino acid level. This bioinformatic study of bovine protein kinases provides a suitable framework for further characterization of their functional and structural properties.},
  author       = {Kabir, Nuzhat N. and Kazi, Julhash U.},
  issn         = {1678-4685},
  keyword      = {aPK,bovine,ePK,kinome},
  language     = {eng},
  number       = {4},
  pages        = {587--591},
  publisher    = {Sociedade Brasileira de Genética},
  series       = {Genetics and Molecular Biology},
  title        = {Comparative analysis of human and bovine protein kinases reveals unique relationship and functional diversity},
  url          = {http://dx.doi.org/10.1590/S1415-47572011005000035},
  volume       = {34},
  year         = {2011},
}