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Grb10 is a dual regulator of receptor tyrosine kinase signaling

Kabir, Nuzhat N. and Kazi, Julhash U. LU (2014) In Molecular Biology Reports 41(4). p.1985-1992
Abstract
The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
InsR IGF-1R FLT3 KIT PDGFR VEGFR RTK Adaptor
in
Molecular Biology Reports
volume
41
issue
4
pages
1985 - 1992
publisher
Springer
external identifiers
  • wos:000333707100011
  • scopus:84897498827
ISSN
0301-4851
DOI
10.1007/s11033-014-3046-4
language
English
LU publication?
yes
id
5dd9cca9-85b3-40de-b2aa-1306ed7573e0 (old id 4250282)
date added to LUP
2014-02-13 17:15:01
date last changed
2017-11-05 03:16:18
@article{5dd9cca9-85b3-40de-b2aa-1306ed7573e0,
  abstract     = {The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.},
  author       = {Kabir, Nuzhat N. and Kazi, Julhash U.},
  issn         = {0301-4851},
  keyword      = {InsR IGF-1R FLT3 KIT PDGFR VEGFR RTK Adaptor},
  language     = {eng},
  number       = {4},
  pages        = {1985--1992},
  publisher    = {Springer},
  series       = {Molecular Biology Reports},
  title        = {Grb10 is a dual regulator of receptor tyrosine kinase signaling},
  url          = {http://dx.doi.org/10.1007/s11033-014-3046-4},
  volume       = {41},
  year         = {2014},
}