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Family history and its association to curve size and treatment in 1,463 patients with idiopathic scoliosis

Grauers, Anna ; Danielsson, Aina ; Karlsson, Magnus LU ; Ohlin, Acke LU and Gerdhem, Paul (2013) In European Spine Journal 22(11). p.2421-2426
Abstract
To study family history in relation to curve severity, gender, age at diagnosis and treatment in idiopathic scoliosis. A self-assessment questionnaire on family history of scoliosis was administered to 1,463 untreated, brace or surgically treated idiopathic scoliosis patients. Out of the 1,463 patients, 51 % had one or more relatives with scoliosis. There was no significant difference between females and males, nor between juvenile and adolescent study participants in this respect (p = 0.939 and 0.110, respectively). There was a significant difference in maximum curve size between patients with one or more relatives with scoliosis (median 35A degrees, interquartile range 25) and patients without any relative with scoliosis (median 32A... (More)
To study family history in relation to curve severity, gender, age at diagnosis and treatment in idiopathic scoliosis. A self-assessment questionnaire on family history of scoliosis was administered to 1,463 untreated, brace or surgically treated idiopathic scoliosis patients. Out of the 1,463 patients, 51 % had one or more relatives with scoliosis. There was no significant difference between females and males, nor between juvenile and adolescent study participants in this respect (p = 0.939 and 0.110, respectively). There was a significant difference in maximum curve size between patients with one or more relatives with scoliosis (median 35A degrees, interquartile range 25) and patients without any relative with scoliosis (median 32A degrees, interquartile range 23) (p = 0.022). When stratifying patients according to treatment (observation, brace treatment or surgery), we found that it was more common to have a relative with scoliosis among the treated patients (p = 0.011). The OR for being treated was 1.32 (95 % CI 1.06-1.64) when the patient had a relative with scoliosis, compared to not having. Larger curve sizes were found in patients with a family history of scoliosis than in the ones without. No relation between family history and gender or between family history and age at onset of idiopathic scoliosis was found. Although the presence of a family history of scoliosis may not be a strong prognostic risk factor, it indicates that these patients are at higher risk of developing a more severe curve. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adolescent idiopathic scoliosis, Juvenile idiopathic scoliosis, Heredity, Prognosis, Curve severity
in
European Spine Journal
volume
22
issue
11
pages
2421 - 2426
publisher
Springer
external identifiers
  • wos:000327396900010
  • scopus:84890552667
  • pmid:23801015
ISSN
0940-6719
DOI
10.1007/s00586-013-2860-z
language
English
LU publication?
yes
id
d1e2811c-2c72-4210-b82e-7e6cf0453533 (old id 4274257)
date added to LUP
2016-04-01 10:48:52
date last changed
2020-09-16 01:29:36
@article{d1e2811c-2c72-4210-b82e-7e6cf0453533,
  abstract     = {To study family history in relation to curve severity, gender, age at diagnosis and treatment in idiopathic scoliosis. A self-assessment questionnaire on family history of scoliosis was administered to 1,463 untreated, brace or surgically treated idiopathic scoliosis patients. Out of the 1,463 patients, 51 % had one or more relatives with scoliosis. There was no significant difference between females and males, nor between juvenile and adolescent study participants in this respect (p = 0.939 and 0.110, respectively). There was a significant difference in maximum curve size between patients with one or more relatives with scoliosis (median 35A degrees, interquartile range 25) and patients without any relative with scoliosis (median 32A degrees, interquartile range 23) (p = 0.022). When stratifying patients according to treatment (observation, brace treatment or surgery), we found that it was more common to have a relative with scoliosis among the treated patients (p = 0.011). The OR for being treated was 1.32 (95 % CI 1.06-1.64) when the patient had a relative with scoliosis, compared to not having. Larger curve sizes were found in patients with a family history of scoliosis than in the ones without. No relation between family history and gender or between family history and age at onset of idiopathic scoliosis was found. Although the presence of a family history of scoliosis may not be a strong prognostic risk factor, it indicates that these patients are at higher risk of developing a more severe curve.},
  author       = {Grauers, Anna and Danielsson, Aina and Karlsson, Magnus and Ohlin, Acke and Gerdhem, Paul},
  issn         = {0940-6719},
  language     = {eng},
  number       = {11},
  pages        = {2421--2426},
  publisher    = {Springer},
  series       = {European Spine Journal},
  title        = {Family history and its association to curve size and treatment in 1,463 patients with idiopathic scoliosis},
  url          = {http://dx.doi.org/10.1007/s00586-013-2860-z},
  doi          = {10.1007/s00586-013-2860-z},
  volume       = {22},
  year         = {2013},
}