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Family history of head and neck cancers

Li, Xinjun LU ; Koskinen, Anni I. ; Hemminki, Otto ; Försti, Asta LU ; Sundquist, Jan LU ; Sundquist, Kristina LU and Hemminki, Kari LU (2021) In Cancers 13(16).
Abstract

Background: Head and neck cancers (HNCs) encompass a heterogeneous group of cancers between the mouth and larynx. Familial clustering in HNCs has been described, but how it influences individual sites and to which extent known risk factors, such as human papilloma virus (HPV) infection, may contribute is not well established. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for HNC with same (concordant) and different (discordant) cancers among first-degree relatives using data from the Swedish Cancer Registry from 1958 to 2018. Results: Incidence for male and female oropharyngeal cancer increased close to four-fold in the past 39 years. Familial HNC was found in 3.4% of the study population,... (More)

Background: Head and neck cancers (HNCs) encompass a heterogeneous group of cancers between the mouth and larynx. Familial clustering in HNCs has been described, but how it influences individual sites and to which extent known risk factors, such as human papilloma virus (HPV) infection, may contribute is not well established. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for HNC with same (concordant) and different (discordant) cancers among first-degree relatives using data from the Swedish Cancer Registry from 1958 to 2018. Results: Incidence for male and female oropharyngeal cancer increased close to four-fold in the past 39 years. Familial HNC was found in 3.4% of the study population, with an overall familial SIR of 1.78. Patients with concordant nasopharyngeal cancer showed a high risk of 23.97, followed by hypopharyngeal cancer (5.43). The husbands of wives with cervical cancer had an increased risk of oropharyngeal cancer. Discussion/Conclusion: Nasopharyngeal cancers lacked associations with lifestyle or HPV associated cancers, suggesting a role for germline genetics, which was also true for the high-risk families of three HNC patients. In the Swedish population with low smoking levels, HPV is becoming a dominant risk factor, emphasizing the need for sexual hygiene and HPV vaccination.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Genetic factors, Human papilloma virus, Oral cancer, Pharyngeal cancer, Smoking
in
Cancers
volume
13
issue
16
article number
4115
publisher
MDPI AG
external identifiers
  • pmid:34439270
  • scopus:85112471505
ISSN
2072-6694
DOI
10.3390/cancers13164115
language
English
LU publication?
yes
id
427d34d1-c7ef-4b91-a6d9-c2cd3c415e86
date added to LUP
2021-09-20 14:48:55
date last changed
2024-06-15 16:32:01
@article{427d34d1-c7ef-4b91-a6d9-c2cd3c415e86,
  abstract     = {{<p>Background: Head and neck cancers (HNCs) encompass a heterogeneous group of cancers between the mouth and larynx. Familial clustering in HNCs has been described, but how it influences individual sites and to which extent known risk factors, such as human papilloma virus (HPV) infection, may contribute is not well established. Patients/methods: We employed standardized incidence ratios (SIRs) to estimate familial risks for HNC with same (concordant) and different (discordant) cancers among first-degree relatives using data from the Swedish Cancer Registry from 1958 to 2018. Results: Incidence for male and female oropharyngeal cancer increased close to four-fold in the past 39 years. Familial HNC was found in 3.4% of the study population, with an overall familial SIR of 1.78. Patients with concordant nasopharyngeal cancer showed a high risk of 23.97, followed by hypopharyngeal cancer (5.43). The husbands of wives with cervical cancer had an increased risk of oropharyngeal cancer. Discussion/Conclusion: Nasopharyngeal cancers lacked associations with lifestyle or HPV associated cancers, suggesting a role for germline genetics, which was also true for the high-risk families of three HNC patients. In the Swedish population with low smoking levels, HPV is becoming a dominant risk factor, emphasizing the need for sexual hygiene and HPV vaccination.</p>}},
  author       = {{Li, Xinjun and Koskinen, Anni I. and Hemminki, Otto and Försti, Asta and Sundquist, Jan and Sundquist, Kristina and Hemminki, Kari}},
  issn         = {{2072-6694}},
  keywords     = {{Genetic factors; Human papilloma virus; Oral cancer; Pharyngeal cancer; Smoking}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{16}},
  publisher    = {{MDPI AG}},
  series       = {{Cancers}},
  title        = {{Family history of head and neck cancers}},
  url          = {{http://dx.doi.org/10.3390/cancers13164115}},
  doi          = {{10.3390/cancers13164115}},
  volume       = {{13}},
  year         = {{2021}},
}