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Time trends between 1987 and 2007 for perfluoroalkyl acids in plasma from Swedish women.

Axmon, Anna LU ; Axelsson, Jonatan LU ; Jakobsson, Kristina LU ; Lindh, Christian LU and Jönsson, Bo A LU (2014) In Chemosphere 102. p.61-67
Abstract
Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these two compounds have been exchanged by other PFAAs, for which time trends have not been as extensively investigated. By the use of 80 plasma samples collected between 1987 and 2007 from healthy women (n=1-9 yearly for 1987-2001, n=15 from 2006, and n=10 from 2007), possible time trends of six PFAAs were assessed. Time trends were evaluated for the entire study period, as well as for three sub-periods. As seen in... (More)
Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these two compounds have been exchanged by other PFAAs, for which time trends have not been as extensively investigated. By the use of 80 plasma samples collected between 1987 and 2007 from healthy women (n=1-9 yearly for 1987-2001, n=15 from 2006, and n=10 from 2007), possible time trends of six PFAAs were assessed. Time trends were evaluated for the entire study period, as well as for three sub-periods. As seen in previous studies, levels of perfluorohexane sulfonate (PFHxS), PFOS, and PFOA peaked during the middle time period (1990-2000), with medians of 0.98ngmL(-1), 18.06ngmL(-1), and 3.73ngmL(-1), respectively. However, levels of perfluorononanic acid (PFNA), perfluorodecanic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) increased over the whole study period and most markedly so after year 2000, with medians of 0.73ngmL(-1), 0.28ngmL(-1), and 0.24ngmL(-1), respectively, during the last study period. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Chemosphere
volume
102
pages
61 - 67
publisher
Elsevier
external identifiers
  • pmid:24440039
  • wos:000333496800010
  • scopus:84893950763
ISSN
1879-1298
DOI
10.1016/j.chemosphere.2013.12.021
language
English
LU publication?
yes
id
69ab7227-761e-4dd2-9384-f4f259909f22 (old id 4291119)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24440039?dopt=Abstract
date added to LUP
2014-02-07 22:48:59
date last changed
2017-09-24 03:04:19
@article{69ab7227-761e-4dd2-9384-f4f259909f22,
  abstract     = {Perfluoroalkyl acids (PFAAs) are a large group of chemicals which are highly persistent in both nature and humans. The use of the most prominent ones, perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA), was reduced in the early 21st century, and since then levels in human matrices have decreased. However, these two compounds have been exchanged by other PFAAs, for which time trends have not been as extensively investigated. By the use of 80 plasma samples collected between 1987 and 2007 from healthy women (n=1-9 yearly for 1987-2001, n=15 from 2006, and n=10 from 2007), possible time trends of six PFAAs were assessed. Time trends were evaluated for the entire study period, as well as for three sub-periods. As seen in previous studies, levels of perfluorohexane sulfonate (PFHxS), PFOS, and PFOA peaked during the middle time period (1990-2000), with medians of 0.98ngmL(-1), 18.06ngmL(-1), and 3.73ngmL(-1), respectively. However, levels of perfluorononanic acid (PFNA), perfluorodecanic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) increased over the whole study period and most markedly so after year 2000, with medians of 0.73ngmL(-1), 0.28ngmL(-1), and 0.24ngmL(-1), respectively, during the last study period.},
  author       = {Axmon, Anna and Axelsson, Jonatan and Jakobsson, Kristina and Lindh, Christian and Jönsson, Bo A},
  issn         = {1879-1298},
  language     = {eng},
  pages        = {61--67},
  publisher    = {Elsevier},
  series       = {Chemosphere},
  title        = {Time trends between 1987 and 2007 for perfluoroalkyl acids in plasma from Swedish women.},
  url          = {http://dx.doi.org/10.1016/j.chemosphere.2013.12.021},
  volume       = {102},
  year         = {2014},
}