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Neutralization of Interleukin 1-beta is associated with preservation of thalamic capillaries after experimental traumatic brain injury

Özen, Ilknur LU ; Clausen, Fredrik LU ; Flygt, Johanna ; Marklund, Niklas LU orcid and Paul, Gesine LU (2024) In Frontiers in Neurology 15.
Abstract

Introduction: Traumatic brain injury to thalamo-cortical pathways is associated with posttraumatic morbidity. Diffuse mechanical forces to white matter tracts and deep grey matter regions induce an inflammatory response and vascular damage resulting in progressive neurodegeneration. Pro-inflammatory cytokines, including interleukin-1β (IL-1β), may contribute to the link between inflammation and the injured capillary network after TBI. This study investigates whether IL-1β is a key contributor to capillary alterations and changes in pericyte coverage in the thalamus and cortex after TBI. Methods: Animals were subjected to central fluid percussion injury (cFPI), a model of TBI causing widespread axonal and vascular pathology, or sham... (More)

Introduction: Traumatic brain injury to thalamo-cortical pathways is associated with posttraumatic morbidity. Diffuse mechanical forces to white matter tracts and deep grey matter regions induce an inflammatory response and vascular damage resulting in progressive neurodegeneration. Pro-inflammatory cytokines, including interleukin-1β (IL-1β), may contribute to the link between inflammation and the injured capillary network after TBI. This study investigates whether IL-1β is a key contributor to capillary alterations and changes in pericyte coverage in the thalamus and cortex after TBI. Methods: Animals were subjected to central fluid percussion injury (cFPI), a model of TBI causing widespread axonal and vascular pathology, or sham injury and randomized to receive a neutralizing anti-IL-1β or a control, anti-cyclosporin A antibody, at 30 min post-injury. Capillary length and pericyte coverage of cortex and thalamus were analyzed by immunohistochemistry at 2- and 7-days post-injury. Results and Conclusion: Our results show that early post-injury attenuation of IL-1β dependent inflammatory signaling prevents capillary damage by increasing pericyte coverage in the thalamus.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
capillaries, cytokine, interleukin-1β, pericytes, platelet derived growth factor (PDGFRβ), traumatic brain injury
in
Frontiers in Neurology
volume
15
article number
1378203
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85193462206
  • pmid:38765267
ISSN
1664-2295
DOI
10.3389/fneur.2024.1378203
language
English
LU publication?
yes
id
42b4dca9-398b-4cb8-9889-cf44efb09739
date added to LUP
2024-06-14 12:55:53
date last changed
2024-06-28 14:14:15
@article{42b4dca9-398b-4cb8-9889-cf44efb09739,
  abstract     = {{<p>Introduction: Traumatic brain injury to thalamo-cortical pathways is associated with posttraumatic morbidity. Diffuse mechanical forces to white matter tracts and deep grey matter regions induce an inflammatory response and vascular damage resulting in progressive neurodegeneration. Pro-inflammatory cytokines, including interleukin-1β (IL-1β), may contribute to the link between inflammation and the injured capillary network after TBI. This study investigates whether IL-1β is a key contributor to capillary alterations and changes in pericyte coverage in the thalamus and cortex after TBI. Methods: Animals were subjected to central fluid percussion injury (cFPI), a model of TBI causing widespread axonal and vascular pathology, or sham injury and randomized to receive a neutralizing anti-IL-1β or a control, anti-cyclosporin A antibody, at 30 min post-injury. Capillary length and pericyte coverage of cortex and thalamus were analyzed by immunohistochemistry at 2- and 7-days post-injury. Results and Conclusion: Our results show that early post-injury attenuation of IL-1β dependent inflammatory signaling prevents capillary damage by increasing pericyte coverage in the thalamus.</p>}},
  author       = {{Özen, Ilknur and Clausen, Fredrik and Flygt, Johanna and Marklund, Niklas and Paul, Gesine}},
  issn         = {{1664-2295}},
  keywords     = {{capillaries; cytokine; interleukin-1β; pericytes; platelet derived growth factor (PDGFRβ); traumatic brain injury}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in Neurology}},
  title        = {{Neutralization of Interleukin 1-beta is associated with preservation of thalamic capillaries after experimental traumatic brain injury}},
  url          = {{http://dx.doi.org/10.3389/fneur.2024.1378203}},
  doi          = {{10.3389/fneur.2024.1378203}},
  volume       = {{15}},
  year         = {{2024}},
}