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Prognostic implications of cytogenetic findings in kidney cancer

Elfving, P. LU ; Mandahl, N. LU ; Lundgren, R. ; Limon, J. ; Bak-Jensen, E. ; Fernö, M. LU ; Olsson, H. LU orcid and Mitelman, F. LU orcid (1997) In British Journal of Urology 80(5). p.698-706
Abstract

Objective. To evaluate the prognostic impact of cytogenetic findings in renal cell carcinoma (RCC). Patients and methods. Tumour cytogenetics, histomorphology, DNA ploidy and S-phase fraction, stage, size, and grade were related to survival in 50 consecutive patients with RCC. The mean follow-up was 3.9 years (median 4.2. range 0-8.8). Results. The predictive probability for recurrence-free survival at 5 years (5-year RFS) for all 50 patients was 0.54. There was a significant association between the degree of cytogenetic complexity and survival, in that patients with five or less aberrations had a better prognosis than those with more than five changes (5-year RFS 0.71 and 0.43, respectively; P < 0.05). Patients with del(8p)/-8, +12,... (More)

Objective. To evaluate the prognostic impact of cytogenetic findings in renal cell carcinoma (RCC). Patients and methods. Tumour cytogenetics, histomorphology, DNA ploidy and S-phase fraction, stage, size, and grade were related to survival in 50 consecutive patients with RCC. The mean follow-up was 3.9 years (median 4.2. range 0-8.8). Results. The predictive probability for recurrence-free survival at 5 years (5-year RFS) for all 50 patients was 0.54. There was a significant association between the degree of cytogenetic complexity and survival, in that patients with five or less aberrations had a better prognosis than those with more than five changes (5-year RFS 0.71 and 0.43, respectively; P < 0.05). Patients with del(8p)/-8, +12, and +20 had a significantly worse prognosis compared with those without these aberrations. Of the well-known prognostic variables grade and stage, the former was far better for predicting prognosis. A Spearman correlation test showed a significant covariation of grade with the S-phase fraction, T-stage, and cytogenetic complexity. Conclusion. The degree of cytogenetic complexity and recurrent cytogenetic abnormalities affect the prognosis in RCC, although grade was the most reliable independent prognostic factor predicting disease recurrence.

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author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cytogenetics, Flow cytometry, Follow-up, Kidney neoplasms, S-phase
in
British Journal of Urology
volume
80
issue
5
pages
698 - 706
publisher
Wiley-Blackwell
external identifiers
  • pmid:9393289
  • scopus:0031400657
ISSN
0007-1331
DOI
10.1046/j.1464-410X.1997.00439.x
language
English
LU publication?
no
id
42fe5057-bbf3-4ed1-a249-f90627c46006
date added to LUP
2019-05-28 16:21:39
date last changed
2024-04-02 05:41:29
@article{42fe5057-bbf3-4ed1-a249-f90627c46006,
  abstract     = {{<p>Objective. To evaluate the prognostic impact of cytogenetic findings in renal cell carcinoma (RCC). Patients and methods. Tumour cytogenetics, histomorphology, DNA ploidy and S-phase fraction, stage, size, and grade were related to survival in 50 consecutive patients with RCC. The mean follow-up was 3.9 years (median 4.2. range 0-8.8). Results. The predictive probability for recurrence-free survival at 5 years (5-year RFS) for all 50 patients was 0.54. There was a significant association between the degree of cytogenetic complexity and survival, in that patients with five or less aberrations had a better prognosis than those with more than five changes (5-year RFS 0.71 and 0.43, respectively; P &lt; 0.05). Patients with del(8p)/-8, +12, and +20 had a significantly worse prognosis compared with those without these aberrations. Of the well-known prognostic variables grade and stage, the former was far better for predicting prognosis. A Spearman correlation test showed a significant covariation of grade with the S-phase fraction, T-stage, and cytogenetic complexity. Conclusion. The degree of cytogenetic complexity and recurrent cytogenetic abnormalities affect the prognosis in RCC, although grade was the most reliable independent prognostic factor predicting disease recurrence.</p>}},
  author       = {{Elfving, P. and Mandahl, N. and Lundgren, R. and Limon, J. and Bak-Jensen, E. and Fernö, M. and Olsson, H. and Mitelman, F.}},
  issn         = {{0007-1331}},
  keywords     = {{Cytogenetics; Flow cytometry; Follow-up; Kidney neoplasms; S-phase}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{698--706}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{British Journal of Urology}},
  title        = {{Prognostic implications of cytogenetic findings in kidney cancer}},
  url          = {{http://dx.doi.org/10.1046/j.1464-410X.1997.00439.x}},
  doi          = {{10.1046/j.1464-410X.1997.00439.x}},
  volume       = {{80}},
  year         = {{1997}},
}