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Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice

el-Din, Sayed H. Seif; El-Lakkany, Naglaa M.; Mohamed, Mona A.; Hamed, Manal M.; Sterner, Olov LU and Botros, Sanaa S. (2014) In Pharmaceutical Biology 52(2). p.144-150
Abstract
Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z.... (More)
Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z. officinale-treated group) similarly treated as the first batch in addition to the antacid ranitidine (30 mg/kg) 1 h before extract administration. Safety, worm recovery, tissues egg load and oogram pattern were assessed. Results: Calotropis procera latex and flower extracts are toxic (50-70% mortality) even in a small dose (250 mg/kg) before washing off their toxic rubber. Zingiber officinale extract insignificantly decrease (7.26%) S. mansoni worms. When toxic rubber was washed off and ranitidine was used, C. procera (stem latex and flowers) and F. elastica extracts revealed significant S. mansoni worm reductions by 45.31, 53.7 and 16.71%, respectively. Moreover, C. procera extracts produced significant reductions in tissue egg load (similar to 34-38.5%) and positively affected oogram pattern. Conclusion: The present study may be useful to supplement information with regard to C. procera and F. elastica antischistosomal activity and provide a basis for further experimental trials. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Asclepiadaceae, moraceae, oogram pattern, tissue egg load, worm burden, zingiberaceae
in
Pharmaceutical Biology
volume
52
issue
2
pages
144 - 150
publisher
Informa Healthcare
external identifiers
  • wos:000329301800002
  • scopus:84891776975
ISSN
1744-5116
DOI
10.3109/13880209.2013.818041
language
English
LU publication?
yes
id
c7817a6a-29a8-4927-b327-ffbfd8e19296 (old id 4326995)
date added to LUP
2014-02-28 09:54:51
date last changed
2017-08-27 03:27:26
@article{c7817a6a-29a8-4927-b327-ffbfd8e19296,
  abstract     = {Context: Calotropis procera (Ait.) R. Br. (Asclepiadaceae), Ficus elastica Roxb. (Moraceae) and Zingiber officinale Roscoe (Zingiberaceae) have been traditionally used to treat many diseases. Objective: The antischistosomal activity of these plant extracts was evaluated against Schistosoma mansoni. Materials and methods: Male mice exposed to 80 +/- 10 cercariae per mouse were divided into two batches. The first was divided into five groups: (I) infected untreated, while groups from (II-V) were treated orally (500 mg/kg for three consecutive days) by aqueous stem latex and flowers of C. procera, latex of F. elastica and ether extract of Z. officinale, respectively. The second batch was divided into four comparable groups (except Z. officinale-treated group) similarly treated as the first batch in addition to the antacid ranitidine (30 mg/kg) 1 h before extract administration. Safety, worm recovery, tissues egg load and oogram pattern were assessed. Results: Calotropis procera latex and flower extracts are toxic (50-70% mortality) even in a small dose (250 mg/kg) before washing off their toxic rubber. Zingiber officinale extract insignificantly decrease (7.26%) S. mansoni worms. When toxic rubber was washed off and ranitidine was used, C. procera (stem latex and flowers) and F. elastica extracts revealed significant S. mansoni worm reductions by 45.31, 53.7 and 16.71%, respectively. Moreover, C. procera extracts produced significant reductions in tissue egg load (similar to 34-38.5%) and positively affected oogram pattern. Conclusion: The present study may be useful to supplement information with regard to C. procera and F. elastica antischistosomal activity and provide a basis for further experimental trials.},
  author       = {el-Din, Sayed H. Seif and El-Lakkany, Naglaa M. and Mohamed, Mona A. and Hamed, Manal M. and Sterner, Olov and Botros, Sanaa S.},
  issn         = {1744-5116},
  keyword      = {Asclepiadaceae,moraceae,oogram pattern,tissue egg load,worm burden,zingiberaceae},
  language     = {eng},
  number       = {2},
  pages        = {144--150},
  publisher    = {Informa Healthcare},
  series       = {Pharmaceutical Biology},
  title        = {Potential effect of the medicinal plants Calotropis procera, Ficus elastica and Zingiber officinale against Schistosoma mansoni in mice},
  url          = {http://dx.doi.org/10.3109/13880209.2013.818041},
  volume       = {52},
  year         = {2014},
}