Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Comparisons of Risk Factors for Abdominal Aortic Aneurysm and Coronary Heart Disease : A Prospective Cohort Study

Xiao, Jun LU ; Borné, Yan LU ; Bao, Xue LU ; Persson, Margaretha LU orcid ; Gottsäter, Anders LU ; Acosta, Stefan LU orcid and Engström, Gunnar LU (2021) In Angiology 72(1). p.24-31
Abstract

Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lunn-McNeil method; 447 participants developed AAA and 3129 developed CHD. After multivariate adjustments, smoking, antihypertensive medications, lipid-lowing medications, systolic and diastolic blood pressures, apolipoprotein (Apo) A1 (inversely), ApoB, ApoB/ApoA1 ratio, total leukocyte count, neutrophil count, and neutrophil to lymphocyte ratio... (More)

Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lunn-McNeil method; 447 participants developed AAA and 3129 developed CHD. After multivariate adjustments, smoking, antihypertensive medications, lipid-lowing medications, systolic and diastolic blood pressures, apolipoprotein (Apo) A1 (inversely), ApoB, ApoB/ApoA1 ratio, total leukocyte count, neutrophil count, and neutrophil to lymphocyte ratio were associated with the risks of both AAA and CHD. When comparing risk factor profiles for the 2 diseases, smoking, diastolic blood pressure, ApoA1, and ApoB/ApoA1 ratio had stronger associations with risk of AAA than with risk of CHD, while diabetes and unmarried status showed increased risk of CHD, but not of AAA (all P values for equal association <.01). The results from this big population study confirm that the risk factor profiles for AAA and CHD show not only many similarities but also several important differences.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
abdominal aortic aneurysm, coronary heart disease, diabetes mellitus, proportional hazards models, smoking
in
Angiology
volume
72
issue
1
pages
8 pages
publisher
SAGE Publications
external identifiers
  • scopus:85089097370
  • pmid:32762347
ISSN
0003-3197
DOI
10.1177/0003319720946976
language
English
LU publication?
yes
id
43294b79-f8b0-4fd2-aa4d-39056e1edb9f
date added to LUP
2020-08-19 09:24:49
date last changed
2024-06-26 20:49:13
@article{43294b79-f8b0-4fd2-aa4d-39056e1edb9f,
  abstract     = {{<p>Even though abdominal aortic aneurysm (AAA) and coronary heart disease (CHD) are both related to atherosclerosis, there could be important differences in risk factors. Based on Malmö Diet and Cancer Cohort, the incidence of AAA and CHD was followed prospectively. Cox regression was used to calculate the association of each factor with AAA and CHD and hazards ratio were compared using a modified Lunn-McNeil method; 447 participants developed AAA and 3129 developed CHD. After multivariate adjustments, smoking, antihypertensive medications, lipid-lowing medications, systolic and diastolic blood pressures, apolipoprotein (Apo) A1 (inversely), ApoB, ApoB/ApoA1 ratio, total leukocyte count, neutrophil count, and neutrophil to lymphocyte ratio were associated with the risks of both AAA and CHD. When comparing risk factor profiles for the 2 diseases, smoking, diastolic blood pressure, ApoA1, and ApoB/ApoA1 ratio had stronger associations with risk of AAA than with risk of CHD, while diabetes and unmarried status showed increased risk of CHD, but not of AAA (all P values for equal association &lt;.01). The results from this big population study confirm that the risk factor profiles for AAA and CHD show not only many similarities but also several important differences.</p>}},
  author       = {{Xiao, Jun and Borné, Yan and Bao, Xue and Persson, Margaretha and Gottsäter, Anders and Acosta, Stefan and Engström, Gunnar}},
  issn         = {{0003-3197}},
  keywords     = {{abdominal aortic aneurysm; coronary heart disease; diabetes mellitus; proportional hazards models; smoking}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{1}},
  pages        = {{24--31}},
  publisher    = {{SAGE Publications}},
  series       = {{Angiology}},
  title        = {{Comparisons of Risk Factors for Abdominal Aortic Aneurysm and Coronary Heart Disease : A Prospective Cohort Study}},
  url          = {{http://dx.doi.org/10.1177/0003319720946976}},
  doi          = {{10.1177/0003319720946976}},
  volume       = {{72}},
  year         = {{2021}},
}