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Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.

Lehn, Sophie LU ; Tobin, Nicholas P LU ; Sims, Andrew H ; Stål, Olle ; Jirström, Karin LU ; Axelson, Håkan LU and Landberg, Göran LU (2014) In BMC Cancer 14(1).
Abstract
Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
BMC Cancer
volume
14
issue
1
article number
119
publisher
BioMed Central (BMC)
external identifiers
  • pmid:24559095
  • wos:000332526900002
  • scopus:84894668015
  • pmid:24559095
ISSN
1471-2407
DOI
10.1186/1471-2407-14-119
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Molecular pathology (013031700), Pathology, (Lund) (013030000), Division of Translational Cancer Research (013250500), Pathology (Malmö) (013031000)
id
dbbaedb4-e770-45a5-a850-63cead7f763e (old id 4334304)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24559095?dopt=Abstract
date added to LUP
2016-04-01 12:54:47
date last changed
2021-10-10 04:19:26
@article{dbbaedb4-e770-45a5-a850-63cead7f763e,
  abstract     = {Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast cancer by examining gene and protein expression in subgroups of patient material and by downregulating YAP1 in vitro and studying its role in response to the widely used anti-estrogen tamoxifen.},
  author       = {Lehn, Sophie and Tobin, Nicholas P and Sims, Andrew H and Stål, Olle and Jirström, Karin and Axelson, Håkan and Landberg, Göran},
  issn         = {1471-2407},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central (BMC)},
  series       = {BMC Cancer},
  title        = {Decreased expression of Yes-associated protein is associated with outcome in the luminal A breast cancer subgroup and with an impaired tamoxifen response.},
  url          = {https://lup.lub.lu.se/search/files/3043258/4693310.pdf},
  doi          = {10.1186/1471-2407-14-119},
  volume       = {14},
  year         = {2014},
}