Obstructive sleep apnea syndrome in siblings : an 8-year Swedish follow-up study
(2008) In Sleep 31(6). p.23-817- Abstract
BACKGROUND: Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics.
OBJECTIVE: To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex.
DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized... (More)
BACKGROUND: Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics.
OBJECTIVE: To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex.
DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized as having or not having a sibling with OSAS, based on the presence or absence of the disorder in at least 1 of their siblings. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for men and women with a sibling with OSAS, compared with men and women in the reference group (SIR = 1).
RESULTS: After accounting for socioeconomic status, age, geographic region, and period of diagnosis, men with at least 1 sibling who had OSAS had a SIR of 3.42 (95% CI, 2.18-5.36); the corresponding SIR in women was 3.25 (95% CI, 1.84-5.65).
CONCLUSIONS: Our results indicate that physicians should consider family history of OSAS when deciding whether to refer a patient for further sleep examinations.
(Less)
- author
- Sundquist, Jan LU ; Li, Xinjun LU ; Friberg, Danielle ; Hemminki, Kari LU and Sundquist, Kristina LU
- publishing date
- 2008-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Aged, Female, Follow-Up Studies, Hospitalization/statistics & numerical data, Humans, Male, Middle Aged, Siblings, Sleep Apnea, Obstructive/genetics, Sweden/epidemiology
- in
- Sleep
- volume
- 31
- issue
- 6
- pages
- 7 pages
- publisher
- Oxford University Press
- external identifiers
-
- scopus:44949162311
- pmid:18548826
- ISSN
- 0161-8105
- DOI
- 10.1093/sleep/31.6.817
- language
- English
- LU publication?
- no
- id
- 436b3681-f4c0-4e43-be79-275cd722995f
- date added to LUP
- 2019-01-30 10:57:29
- date last changed
- 2024-07-23 08:17:25
@article{436b3681-f4c0-4e43-be79-275cd722995f,
abstract = {{<p>BACKGROUND: Understanding the genetic transmission of obstructive sleep apnea syndrome (OSAS) will help clinicians identify patients at risk and offer opportunities for intervention and treatment at specialist clinics.</p><p>OBJECTIVE: To estimate familial risk of hospitalization for OSAS in the adult population of Sweden, and to determine if there are any differences by age and sex.</p><p>DESIGN, SETTING, AND PARTICIPANTS: Using the MigMed database at the Karolinska Institute, we divided the population of Sweden into sibling groups based on a shared mother and father and ascertained the presence or absence of a primary hospital diagnosis of OSAS in each individual during the follow-up period, 1997 to 2004. Individuals were categorized as having or not having a sibling with OSAS, based on the presence or absence of the disorder in at least 1 of their siblings. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated for men and women with a sibling with OSAS, compared with men and women in the reference group (SIR = 1).</p><p>RESULTS: After accounting for socioeconomic status, age, geographic region, and period of diagnosis, men with at least 1 sibling who had OSAS had a SIR of 3.42 (95% CI, 2.18-5.36); the corresponding SIR in women was 3.25 (95% CI, 1.84-5.65).</p><p>CONCLUSIONS: Our results indicate that physicians should consider family history of OSAS when deciding whether to refer a patient for further sleep examinations.</p>}},
author = {{Sundquist, Jan and Li, Xinjun and Friberg, Danielle and Hemminki, Kari and Sundquist, Kristina}},
issn = {{0161-8105}},
keywords = {{Adult; Aged; Female; Follow-Up Studies; Hospitalization/statistics & numerical data; Humans; Male; Middle Aged; Siblings; Sleep Apnea, Obstructive/genetics; Sweden/epidemiology}},
language = {{eng}},
number = {{6}},
pages = {{23--817}},
publisher = {{Oxford University Press}},
series = {{Sleep}},
title = {{Obstructive sleep apnea syndrome in siblings : an 8-year Swedish follow-up study}},
url = {{http://dx.doi.org/10.1093/sleep/31.6.817}},
doi = {{10.1093/sleep/31.6.817}},
volume = {{31}},
year = {{2008}},
}