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High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.

Paulsson, Johan F; Ludvigsson, Johnny; Carlsson, Annelie LU ; Casas, Rosaura; Forsander, Gun; Ivarsson, Sten LU ; Kockum, Ingrid; Lernmark, Åke LU ; Marcus, Claude and Lindblad, Bengt LU , et al. (2014) In PLoS ONE 9(3).
Abstract
Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.
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PLoS ONE
volume
9
issue
3
publisher
Public Library of Science
external identifiers
  • pmid:24671002
  • wos:000333677000107
  • scopus:84899802911
ISSN
1932-6203
DOI
10.1371/journal.pone.0093053
language
English
LU publication?
yes
id
3ab51cc1-919c-4f0e-a850-588702ebaee8 (old id 4379653)
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http://www.ncbi.nlm.nih.gov/pubmed/24671002?dopt=Abstract
date added to LUP
2014-04-04 19:56:39
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2017-10-22 04:20:35
@article{3ab51cc1-919c-4f0e-a850-588702ebaee8,
  abstract     = {Islet amyloid polypeptide (IAPP) is a beta cell hormone secreted together with insulin upon glucose stimulation. IAPP participates in normal glucose regulation, but IAPP is also known for its ability to misfold and form islet amyloid. Amyloid fibrils form through smaller cell toxic intermediates and deposited amyloid disrupts normal islet architecture. Even though IAPP and amyloid formation are much discussed in type 2 diabetes, our aim was to study the significance of IAPP in type 1 diabetes.},
  articleno    = {e93053},
  author       = {Paulsson, Johan F and Ludvigsson, Johnny and Carlsson, Annelie and Casas, Rosaura and Forsander, Gun and Ivarsson, Sten and Kockum, Ingrid and Lernmark, Åke and Marcus, Claude and Lindblad, Bengt and Westermark, Gunilla T},
  issn         = {1932-6203},
  language     = {eng},
  number       = {3},
  publisher    = {Public Library of Science},
  series       = {PLoS ONE},
  title        = {High plasma levels of islet amyloid polypeptide in young with new-onset of type 1 diabetes mellitus.},
  url          = {http://dx.doi.org/10.1371/journal.pone.0093053},
  volume       = {9},
  year         = {2014},
}