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Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice.

Heyman, Lovisa LU ; Axling, Ulrika LU ; Blanco, Narda; Sterner, Olov; Holm, Cecilia LU and Berger, Karin LU (2014) In Journal of Nutrition and Metabolism 2014(Jan 14).
Abstract
Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes. Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (20%) with lingonberry, blackcurrant, bilberry, raspberry, açai, crowberry, prune or blackberry. Results. The groups receiving a high-fat diet supplemented with lingonberries, blackcurrants, raspberries or bilberries gained less weight and had lower fasting insulin levels than the control group receiving high-fat diet without berries. Lingonberries, and also blackcurrants and bilberries, significantly decreased body fat content, hepatic lipid... (More)
Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes. Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (20%) with lingonberry, blackcurrant, bilberry, raspberry, açai, crowberry, prune or blackberry. Results. The groups receiving a high-fat diet supplemented with lingonberries, blackcurrants, raspberries or bilberries gained less weight and had lower fasting insulin levels than the control group receiving high-fat diet without berries. Lingonberries, and also blackcurrants and bilberries, significantly decreased body fat content, hepatic lipid accumulation, and plasma levels of the inflammatory marker PAI-1, as well as mediated positive effects on glucose homeostasis. The group receiving açai displayed increased weight gain and developed large, steatotic livers. Quercetin glycosides were detected in the lingonberry and the blackcurrant diets. Conclusion. Lingonberries were shown to fully or partially prevent the detrimental metabolic effects induced by high-fat diet. Blackcurrants and bilberries had similar properties, but to a lower degree. We propose that the beneficial metabolic effects of lingonberries could be useful in preventing obesity and related disorders. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Nutrition and Metabolism
volume
2014
issue
Jan 14
publisher
Hindawi Publishing Corporation
external identifiers
  • pmid:24669315
  • scopus:84893832238
ISSN
2090-0724
DOI
10.1155/2014/403041
language
English
LU publication?
yes
id
fef145d7-a308-47d2-bd45-3133b5651ce9 (old id 4379689)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24669315?dopt=Abstract
date added to LUP
2014-04-05 14:53:53
date last changed
2017-09-10 03:20:54
@article{fef145d7-a308-47d2-bd45-3133b5651ce9,
  abstract     = {Objective. The aim of the study was to screen eight species of berries for their ability to prevent obesity and metabolic abnormalities associated with type 2 diabetes. Methods. C57BL/6J mice were assigned the following diets for 13 weeks: low-fat diet, high-fat diet or high-fat diet supplemented (20%) with lingonberry, blackcurrant, bilberry, raspberry, açai, crowberry, prune or blackberry. Results. The groups receiving a high-fat diet supplemented with lingonberries, blackcurrants, raspberries or bilberries gained less weight and had lower fasting insulin levels than the control group receiving high-fat diet without berries. Lingonberries, and also blackcurrants and bilberries, significantly decreased body fat content, hepatic lipid accumulation, and plasma levels of the inflammatory marker PAI-1, as well as mediated positive effects on glucose homeostasis. The group receiving açai displayed increased weight gain and developed large, steatotic livers. Quercetin glycosides were detected in the lingonberry and the blackcurrant diets. Conclusion. Lingonberries were shown to fully or partially prevent the detrimental metabolic effects induced by high-fat diet. Blackcurrants and bilberries had similar properties, but to a lower degree. We propose that the beneficial metabolic effects of lingonberries could be useful in preventing obesity and related disorders.},
  articleno    = {403041},
  author       = {Heyman, Lovisa and Axling, Ulrika and Blanco, Narda and Sterner, Olov and Holm, Cecilia and Berger, Karin},
  issn         = {2090-0724},
  language     = {eng},
  number       = {Jan 14},
  publisher    = {Hindawi Publishing Corporation},
  series       = {Journal of Nutrition and Metabolism},
  title        = {Evaluation of Beneficial Metabolic Effects of Berries in High-Fat Fed C57BL/6J Mice.},
  url          = {http://dx.doi.org/10.1155/2014/403041},
  volume       = {2014},
  year         = {2014},
}